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The 5-HT(6) receptor antagonist SB-271046 selectively enhances excitatory neurotransmission in the rat frontal cortex and hippocampus.
TLDR
The selective enhancement of excitatory neurotransmission by SB-271046 is demonstrated for the first time, and mechanistic evidence in support of a possible therapeutic role for 5-HT(6) receptor antagonists in the treatment of cognitive and memory dysfunction is provided.
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In vivo effects of the 5‐HT6 antagonist SB‐271046 on striatal and frontal cortex extracellular concentrations of noradrenaline, dopamine, 5‐HT, glutamate and aspartate
TLDR
The neurochemical effects of a selective 5‐HT6 receptor ligand are demonstrated for the first time using in vivo microdialysis in the freely moving rat by simultaneous measurement of 5‐hydroxytryptamine (5‐HT), dopamine, dopamine, noradrenaline, glutamate and aspartate from the striatum and frontal cortex.
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Central pathways in the pons and midbrain involved in cardiac sympathoexcitatory reflexes in cats
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Excitatory projections from hypothalamic and midbrain defense regions to nucleus paragigantocellularis lateralis in the rat
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The nociceptin receptor-mediated inhibition of the rat rostral ventrolateral medulla neurons in vitro.
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Naloxone reverses inhibitory effect of electroacupuncture on sympathetic cardiovascular reflex responses.
TLDR
The results indicate that the inhibitory effect of EA on the BK-induced pressor response and the consequent improvement of ischemic dysfunction is dependent on the activation of opioid receptors, specifically receptors located in the rVLM.
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[Role of the medial medulla in the inhibitory effect of somatic afferent nerve stimulation on ventricular extrasystoles induced by hypothalamic stimulation in the rabbit].
  • Y. XiaX. Q. GuoP. Li
  • Biology, Medicine
    Sheng li xue bao : [Acta physiologica Sinica]
  • 1 February 1985
TLDR
The results suggest that the inhibitory effect of somatic afferent nervestimulation on HVEs is mediated by activation of opiate and serotonin receptors inthe medial medulla.
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[Role of the ventral medullary area on ventricular extrasystoles induced by hypothalamic stimulation in the rabbit].
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[Inhibitory effect of a microinjection of morphine into the ventral medulla on ventricular extrasystoles induced by hypothalamic stimulation in the rabbit].
TLDR
Results suggest that activation of the opiate receptors in the ventral me-dulla may inhibit HVE, and that the inhibitory effect of DPN stimulation on HVE may be mediated by activation ofThe opiates receptors inThe ventral medulla viaactivation of the caudal raphe nuclei.
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Defence reaction and ventricular extrasystoles induced by hypothalamic stimulation in rabbits
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