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The Predominant Mechanism by Which Ribavirin Exerts Its Antiviral Activity In Vitro against Flaviviruses and Paramyxoviruses Is Mediated by Inhibition of IMP Dehydrogenase
TLDR
Data provide compelling evidence that the predominant mechanism of action of ribavirin in vitro against flavi- and paramyxoviruses is based on inhibition of cellular IMP dehydrogenase activity.
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
TLDR
Optimization of the P2 substituent of the α-ketoamides proved crucial for achieving near-equipotency against the three virus genera and six crystal structures of protease–inhibitor complexes were determined.
Perspectives for the treatment of infections with Flaviviridae.
TLDR
Different strategies that could be pursued to specifically inhibit viral targets and animal models that are available to study the pathogenesis and antiviral strategies are reviewed.
Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri.
TLDR
The isolation and structure elucidation of a series of highly oxygenated daphnane diterpenoid orthoesters bearing an uncommon chlorinated moiety are described and the antiviral activity of trigocherrins A, B and F and trigochersriolides A-D against various emerging pathogens is reported.
Complete genome sequence of Montana Myotis leukoencephalitis virus, phylogenetic analysis and comparative study of the 3' untranslated region of flaviviruses with no known vector.
TLDR
Structural elements in the 3' UTR that are preserved among other flaviviruses have been revealed, as well as elements that distinguish the NKV from the mosquito- and tick-borne flaviviraluses.
The Anti-Yellow Fever Virus Activity of Ribavirin Is Independent of Error-Prone Replication
TLDR
It is demonstrated that inhibition of cellular inosine monophosphate dehydrogenase (IMPDH) activity, and thus depletion of intracellular GTP pools, is the predominant mechanism by which ribavirin inhibits the replication of four flavi- and two paramyxoviruses.
Itraconazole Inhibits Enterovirus Replication by Targeting the Oxysterol-Binding Protein
TLDR
ITZ is identified as a broad-spectrum inhibitor of enteroviruses and it is demonstrated that ITZ inhibits viral RNA replication by targeting oxysterol-binding protein (OSBP) and OSBP-related protein 4 (ORP4).
Prostratin and 12-O-tetradecanoylphorbol 13-acetate are potent and selective inhibitors of Chikungunya virus replication.
TLDR
A chemical study of the Vietnamese plant species Trigonostemon howii led to the isolation of a new tigliane-type diterpenoid, trigowiin A (1), which exhibited moderate antiviral activity in a virus-cell-based assay for Chikungunya virus (CHIKV).
Phosphatidylinositol 4-Kinase III Beta Is Essential for Replication of Human Rhinovirus and Its Inhibition Causes a Lethal Phenotype In Vivo
TLDR
A cell-based antiviral screen against HRV was performed with a subset of a proprietary compound collection, and an aminothiazole series with pan-HRV species and enteroviral activity was found to act at the level of replication in the HRV infectious cycle.
Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi.
TLDR
Even though several extracts and fractions showed significant selective antiviral activity in the CHIKV virus-cell-based assay, none of the purified compounds did, and significant inhibition was observed with betulinic acid 3β-caffeate in the DENV RNA polymerase assay.
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