Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
- D. Klionsky, K. Abdelmohsen, S. Zughaier
- BiologyAutophagy
- 18 April 2012
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
- M. Nalls, C. Blauwendraat, Futao Zhang
- Biology, MedicineLancet Neurology
- 1 December 2019
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
- E. Greggio, S. Jain, M. Cookson
- BiologyNeurobiology of Disease
- 1 August 2006
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
- Junpeng Deng, P. Lewis, E. Greggio, Eli Sluch, A. Beilina, M. Cookson
- Biology, ChemistryProceedings of the National Academy of Sciences
- 5 February 2008
The crystal structure of the LRRK2 ROC domain in complex with GDP-Mg2+ at 2.0-Å resolution shows a dimeric fold generated by extensive domain-swapping, resulting in a pair of active sites constructed with essential functional groups contributed from both monomers.
α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?
A British family with young-onset Parkinson’s disease and a G51D SNCA mutation that segregates with the disease and post-mortem brain examination of the proband revealed atrophy affecting frontal and temporal lobes, which could aid in understanding of α-synuclein biology and its impact on disease phenotype.
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
This model represents a new experimental system to identify compounds that reduce levels of α- synuclein, and to investigate the mechanistic basis of neurodegeneration caused by α-synuclein dysfunction.
The Parkinson Disease-associated Leucine-rich Repeat Kinase 2 (LRRK2) Is a Dimer That Undergoes Intramolecular Autophosphorylation*
- E. Greggio, Ibardo Zambrano, M. Cookson
- Biology, ChemistryJournal of Biological Chemistry
- 13 June 2008
It is shown that L RRK2 predominantly exists as a dimer under native conditions, a state that appears to be stabilized by multiple domain-domain interactions and it is demonstrated that LRRK2 undergoes intramolecular autophosphorylation.
The Parkinson ’ s disease – linked proteins Fbxo 7 and Parkin interact to mediate mitophagy
- V. Burchell, D. Nelson, H. Laman
- Biology
The Parkinson’s disease genes Fbxo7 and Parkin interact to mediate mitophagy
- V. Burchell, D. Nelson, H. Plun-Favreau
- BiologyNature Neuroscience
- 23 July 2013
It is shown that Fbxo7 participates in mitochondrial maintenance through direct interaction with PINK1 and Parkin and acts in Parkin-mediated mitophagy, emphasizing the importance of mitochondrial dysfunction in Parkinson's disease pathogenesis.
Genetic neuropathology of Parkinson's disease.
- M. Cookson, J. Hardy, P. Lewis
- Biology, PsychologyInternational Journal of Clinical and…
- 2008
The neuropathological data relating to familial cases of PD is reviewed and the complicated relationships between the genetically defined cases and the two key pathological events seen in PD are discussed, namely loss of dopaminergic neurons in the substantia nigra pars compacta and the formation of protein inclusions in the neurons that survive to the end stage of the disease course.
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