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Gender differences in hepatic expression of flavin-containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in mice.
Examination of protein levels among Swiss-Webster, C57BL/6, and DBA/2 strains revealed a gender-dependent expression of FMO isozymes identical to the CD-1 strain, which demonstrates no gender-selective expression in mice and may be regulated by different mechanisms. Expand
Organophosphates : chemistry, fate, and effects
(Section Headings): Introduction. Metabolic Fate. Toxic Effects--Noncholinergic Biochemical. Toxic Effects--Organismal. Summary and Conclusions.
Pesticides: an important but underused model for the environmental health sciences.
This paper attempts to indicate the importance and present status of studies of the mammalian metabolism of pesticides and indicates the need for further use of this model. Expand
Olfactory Toxicity of Methimazole: Dose-Response and Structure-Activity Studies and Characterization of Flavin-Containing Monooxygenase Activity in the Long-Evans Rat Olfactory Mucosa
It is suggested that characterization of human olfactory mucosal FMO activity may be necessary to assess the potential for human risk associated with therapeutic exposure to methimazole. Expand
Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids.
In males and females, F MO5 levels were unaffected by gonadectomy or hormone administration, thus indicating a sex hormone-independent mechanism of regulation for this isoform, and Interestingly, FMO1 protein levels were increased in sexually intact males following treatment with 17 beta-estradiol; however, only a slight increase in FMO3 protein level was observed. Expand
The reaction of the bladder epithelium of mice, following stimulation with a carcinogen, 4‐ethylsulphonylnaphthalene‐1‐sulphonamide (ENS), was studied to find out the intensity and timing of the onset of cell division in the bladder tissue of individual animals. Expand
Metabolism of thioridazine by microsomal monooxygenases: relative roles of P450 and flavin-containing monooxygenase.
1. The metabolism of thioridazine by the flavin-containing monooxygenase (FMO) of mouse liver and several P450 isozymes was examined using microsomes, purified FMO, and expressed P450 isozymes.Expand
Differences in oxidative dearylation and desulfuration of fenitrothion by cytochrome P-450 isozymes and in the subsequent inhibition of monooxygenase activity
Abstract The organophosphorus insecticide, fenitrothion ( O,O -dimethyl O -(3-methyl-4-nitrophenyl) phosphorothioate), a substrate for the cytochrome P -450 ( P -450) monooxygenase system, yields theExpand
Enzymatic and immunohistochemical studies on the role of cytochrome P450 and the flavin-containing monooxygenase of mouse skin in the metabolism of pesticides and other xenobiotics
Abstract The cytochrome P450 (P450) content, the cytochrome c reductase activity, the metabolism of a variety of P450 substrates, and the presence and role of flavin-containing monooxygenase (FMO) inExpand