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Leptospirosis: a zoonotic disease of global importance.
Leptospirosis in humans.
Data emerging from prospective surveillance studies suggest that most human leptospiral infections in endemic areas are mild or asymptomatic, and patients progressing to multisystem organ failure have widespread hematogenous dissemination of pathogens.
The Leptospiral Major Outer Membrane Protein LipL32 Is a Lipoprotein Expressed during Mammalian Infection
The cloning of the gene encoding the 32-kDa lipoprotein, designated LipL32, the most prominent protein in the leptospiral protein profile, is reported, indicating that LipL 32 may be important in the pathogenesis, diagnosis, and prevention ofLeptospirosis.
Evaluation of Four Commercially Available Rapid Serologic Tests for Diagnosis of Leptospirosis
The ease of use and significantly high sensitivity and specificity of DST and ELISA make these good choices for diagnostic testing, which were quite close to the LCA estimates.
Bacteriologic characterization of 36 strains of Roseomonas species and proposal of Roseomonas mucosa sp nov and Roseomonas gilardii subsp rosea subsp nov.
- Xiang Y. Han, A. S. Pham, J. Tarrand, K. Rolston, L. Helsel, P. Levett
- BiologyAmerican journal of clinical pathology
- 1 August 2003
Unique patterns of biochemical reactions were established for these Roseomonas species, which may assist routine identification of these organisms.
Detection of pathogenic leptospires by real-time quantitative PCR.
- P. Levett, R. Morey, R. Galloway, D. Turner, A. Steigerwalt, L. Mayer
- Medicine, BiologyJournal of Medical Microbiology
A real-time PCR assay was developed using a 423 bp target on the lipL32 gene, which is conserved among pathogenic serovars of LEPTOSPIRA, which has the potential to facilitate rapid, sensitive diagnosis of acute leptospirosis.
Leptospirosis: A forgotten zoonosis?
- P. Levett
- 1 October 2004
The effect of slurry storage and anaerobic digestion on survival of pathogenic bacteria.
The decline in viable numbers of Salmonella typhimurium, Yersinia enterocolitica and Listeria monocytogene in beef cattle slurry is temperature-dependent; they decline more rapidly at 17 degrees C…
Atopic Dermatitis Is Associated with a Functional Mutation in the Promoter of the C-C Chemokine RANTES1
The findings suggest that the mutant allele of the RANTES gene contributes to the development of atopic dermatitis and its potential role in other inflammatory and infectious disorders, particularly among individuals of African ancestry, remains to be determined.
Usefulness of serologic analysis as a predictor of the infecting serovar in patients with severe leptospirosis.
- P. Levett
- MedicineClinical Infectious Diseases
- 15 February 2003
Serologic analysis appeared to be of little value for the identification of the infecting serovar in individual cases of leptospirosis in humans, and presumptive serogroup reactivity data should be used only to gain a broad idea of the serogroups present at the population level.