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NOD.c3c4 congenic mice develop autoimmune biliary disease that serologically and pathogenetically models human primary biliary cirrhosis
TLDR
It is demonstrated that NOD.c3c4 mice congenically derived from the nonobese diabetic strain develop an autoimmune biliary disease (ABD) that models human PBC, and the first ABD (Abd) locus is defined using a congenic mapping approach. Expand
Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic‐metabolizing bacterium
TLDR
It is proposed that N. aromaticivorans is a candidate for the induction of PBC, based on protein homology, capacity to metabolize xenobiotics as well as modulate estrogens, its presence in feces, and specific immunologic response. Expand
Current Immunological and Molecular Biological Perspectives on Seafood Allergy: A Comprehensive Review
TLDR
Future research focusing on the immunological cross-reactivity and discovery of novel allergens will greatly facilitate the management of seafood allergies and the design of effective and life-long allergen-specific immunotherapies. Expand
The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase
TLDR
A 603-bp fragment that codes for a polypeptide containing all of the autoreactivity of the original rat liver cDNA clone is identified and it appears that for this autoantigen, the target of the autoantibodies corresponds to a functional site of the dihydrolipoamide acetyltransferase. Expand
Cloning, expression, and primary structure of Metapenaeus ensis tropomyosin, the major heat-stable shrimp allergen.
TLDR
The primary structure of the major heat-stable allergen of shrimp is determined by cloning, expression, nucleotide sequencing, and amino acid sequence determination of an IgE-reactive cDNA clone, Met e I, isolated from a Metapenaeus ensis expression library in lambda gt 11. Expand
The Implication of Vitamin D and Autoimmunity: a Comprehensive Review
TLDR
Five major areas in vitamin D biology of high immunological significance are discussed, including the metabolism of vitamin D; the significance of Vitamin D receptor polymorphisms in autoimmune diseases, such as multiple sclerosis, type 1 diabetes mellitus, and systemic lupus erythematosus; and the therapeutic effects ofitamin D supplementation on disease severity and progression. Expand
Liver Autoimmunity Triggered by Microbial Activation of Natural Killer T Cells
TLDR
It is shown that infection of mice with N. aromaticivorans induced signature antibodies against microbial PDC-E2 and its mitochondrial counterpart but also triggered chronic T cell-mediated autoimmunity against small bile ducts, illustrating the importance of early microbial activation of NKT cells in the initiation of autonomous, organ-specific autoimmonity. Expand
A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA‐negative primary biliary cirrhosis
TLDR
The development of this bead assay reflects the potential for automated detection with rapid and reliable assaying and further highlights the diminished number of truly AMA‐negative PBC patients. Expand
The autoimmune basis of alopecia areata: a comprehensive review.
TLDR
Recent studies suggest that intervention of the JAK pathway may have a potential therapeutic efficacy for AA, and multiple treatment options including the use of broad acting corticosteroids appear to be relatively effective in mild cases. Expand
Analysis of the Foxp3/Scurfin Gene in Crohn's Disease
TLDR
SNPs of the Foxp3 gene are not significantly associated with CD but are associated with PBC, and there was a significance difference of the comparison between PBC patients and controls in the IVS9+459 SNP. Expand
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