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  • Influence
Patients with primary biliary cirrhosis react against a ubiquitous xenobiotic‐metabolizing bacterium
Infectious and environmental agents have been proposed as immunologic triggers for primary biliary cirrhosis (PBC). Recently, a ubiquitous organism that metabolizes organic compounds and estrogens,Expand
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Liver Autoimmunity Triggered by Microbial Activation of Natural Killer T Cells
Summary Humans with primary biliary cirrhosis (PBC), a disease characterized by the destruction of small bile ducts, exhibit signature autoantibodies against mitochondrial Pyruvate DehydrogenaseExpand
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Autoimmune acute liver failure: Proposed clinical and histological criteria
Identifying autoimmune hepatitis as the etiology of acute liver failure (ALF) is potentially important, because administering corticosteroids might avoid the need for liver transplantation. However,Expand
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Identification and molecular characterization of Charybdis feriatus tropomyosin, the major crab allergen.
BACKGROUND Crab sensitivity is one of the most common seafood allergies. However, to date, there has been no report on the molecular characterization of crab allergens and no comparative analysisExpand
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IgE reactivity against a cross-reactive allergen in crustacea and mollusca: evidence for tropomyosin as the common allergen.
BACKGROUND Although cross-reactivity between mollusks and other crustaceans in shrimp-sensitive subjects has been reported, the mechanism of this allergenic cross-reactivity has not been studied inExpand
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A sensitive bead assay for antimitochondrial antibodies: Chipping away at AMA‐negative primary biliary cirrhosis
The antimitochondrial response in primary biliary cirrhosis (PBC) is the most highly directed and specific self‐reacting antibody in human immunopathology. Originally, antimitochondrial antibodiesExpand
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Use of a designer triple expression hybrid clone for three different lipoyl domain for the detection of antimitochondrial autoantibodies
The detection of antimitochondrial autoantibodies (AMAs) is critical in the diagnosis of primary biliary cirrhosis (PBC). However, conventional laboratory assays to detect AMA are dependent on theExpand
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Mechanisms of environmental influence on human autoimmunity: a National Institute of Environmental Health Sciences expert panel workshop.
The mechanisms leading to autoimmune diseases remain largely unknown despite numerous lines of experimental inquiry and epidemiological evidence. The growing number of genome-wide association studiesExpand
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  • Open Access
Quantitative measurement of autoantibodies to recombinant mitochondrial antigens in patients with primary biliary cirrhosis: Relationship of levels of autoantibodies to disease progression
We examined the clinical usefulness of measurements of antimitochondrial autoantibodies (AMA) in predicting disease progression in patients with primary biliary cirrhosis (PBC). We determined theExpand
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Characterization of antimitochondrial antibodies in healthy adults
The detection of antimitochondrial antibodies (AMAs) is an important criterion for the diagnosis of primary biliary cirrhosis (PBC). During the last decade, the mitochondrial autoantigens have beenExpand
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