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Crystal structure of an anti-carbohydrate antibody directed against Vibrio cholerae O1 in complex with antigen: molecular basis for serotype specificity.
- S. Villeneuve, H. Souchon, P. Alzari
- Chemistry, BiologyProceedings of the National Academy of Sciences…
- 18 July 2000
The crystal structure of the murine Fab S-20-4 from a protective anti-cholera Ab specific for the lipopolysaccharide Ag of the Ogawa serotype has been determined and provides a rational basis toward the development of a synthetic carbohydrate-based anti- cholera vaccine.
On the Antigenic Determinants of the Lipopolysaccharides of Vibrio cholerae O:1, Serotypes Ogawa and Inaba*
Inhibition studies revealed that the binding of purified IgG3 I-24-2 to Ogawa-LPS might be mediated by a region in the junction of the OPS to the lipid-core region of the LPS.
Synthesis of cholestane glycosides bearing OSW-1 disaccharide or its 1-->4-linked analogue and their antitumor activities.
The first total synthesis of the antithrombin III binding site of porcine mucosa heparin
Synthesis of a 3-deoxy-L-iduronic acid containing heparin pentasaccharide to probe the conformation of the antithrombin III binding sequence.
Synthesis of 5(6)-dihydro-OSW-1 analogs bearing three kinds of disaccharides linking at 15-hydroxy and their antitumor activities.
Synthesis of 4″-O-desosaminyl clarithromycin derivatives and their anti-bacterial activities.
Synthesis and cytotoxic activity of two steroids: icogenin aglycone analogs
- Yu-yao Guan, Shu-Zhen Li, P. Lei
- Chemistry, BiologyJournal of Asian natural products research
- 1 May 2017
During the process of icogenin analog research, two cytotoxic steroids were obtained: compound 4 and compound 6 casually and their in vitro antitumor activities were tested by the standard MTT assay.
The synthesis of gracillin and dioscin: two typical representatives of spirostanol glycosides.