P. Leblond

Publications115
h-index28
Citations2,448
Highly Influential Citations116
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Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
There is a constant need for new and improved drugs to combat infectious diseases, cancer, and other major life-threatening conditions. The recent development of genomics-guided approaches for novel… Expand
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Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.
Siderophore-mediated iron acquisition has been well studied in many bacterial pathogens because it contributes to virulence. In contrast, siderophore-mediated iron acquisition by saprophytic bacteria… Expand
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The Streptomyces lividans 66 chromosome contains a 1 MB deletogenic region flanked by two amplifiable regions
Genetic instability in Streptomyces species often involves large deletions sometimes accompanied by DNA amplification. Two such systems in Streptomyces lividans 66 involve the production of mutants… Expand
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Physical map of the Streptomyces lividans 66 genome and comparison with that of the related strain Streptomyces coelicolor A3(2).
A physical map of the chromosome of Streptomyces lividans 66 ZX7 was constructed by ordering the macrorestriction fragments generated from the genomic DNA with the restriction enzymes AseI and DraI.… Expand
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Occurrence of deletions, associated with genetic instability in Streptomyces ambofaciens, is independent of the linearity of the chromosomal DNA.
The chromosomal structures of mutant strains of Streptomyces ambofaciens which have arisen from genetic instability were investigated by using pulsed-field gel electrophoresis and probing with… Expand
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Evolution of the terminal regions of the Streptomyces linear chromosome.
Comparative analysis of the Streptomyces chromosome sequences, between Streptomyces coelicolor, Streptomyces avermitilis, and Streptomyces ambofaciens ATCC23877 (whose partial sequence is released in… Expand
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The unstable region of Streptomyces ambofaciens includes 210 kb terminal inverted repeats flanking the extremities of the linear chromosomal DNA
Physical maps of the chromosomes of three strains of Streptomyces ambofaciens were constructed by ordering AseI fragments generated from the genomic DNA as a single linear chromosome of about 8 Mb.… Expand
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Diversity and Mobility of Integrative and Conjugative Elements in Bovine Isolates of Streptococcusagalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis
ABSTRACT Bovine isolates of Streptococcusagalactiae (n = 76), Streptococcusdysgalactiae subsp. dysgalactiae (n = 32), and Streptococcusuberis (n = 101) were analyzed for the presence of different… Expand
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New insights into the genetic instability of streptomyces.
The high level of genetic instability in Streptomyces ambofaciens is related to large scale DNA rearrangements (deletions and DNA amplifications) which occur within a 2 Mb chromosomal region. The… Expand
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Differential regulation of two closely related integrative and conjugative elements from Streptococcus thermophilus
BackgroundTwo closely related ICEs, ICESt1 and ICESt3, have been identified in the lactic acid bacterium Streptococcus thermophilus. While their conjugation and recombination modules are almost… Expand
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