Skip to search formSkip to main contentSkip to account menu
Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens
There is a constant need for new and improved drugs to combat infectious diseases, cancer, and other major life-threatening conditions. The recent development of genomics-guided approaches for novel…
View on Publisher
Multiple biosynthetic and uptake systems mediate siderophore-dependent iron acquisition in Streptomyces coelicolor A3(2) and Streptomyces ambofaciens ATCC 23877.
TLDR
It is shown that coelichelin and desferrioxamines E and B all function as siderophores in this organism and that at least one of these metabolites is required for growth under defined conditions even in the presence of significant quantities of ferric iron.
View on PubMed
The Streptomyces lividans 66 chromosome contains a 1 MB deletogenic region flanked by two amplifiable regions
Genetic instability in Streptomyces species often involves large deletions sometimes accompanied by DNA amplification. Two such systems in Streptomyces lividans 66 involve the production of mutants…
View on Springer
Physical map of the Streptomyces lividans 66 genome and comparison with that of the related strain Streptomyces coelicolor A3(2)
TLDR
A physical map of the chromosome of Streptomyces lividans 66 ZX7 was constructed by ordering the macrorestriction fragments generated from the genomic DNA with the restriction enzymes AseI and DraI, revealing a common structure with an identical ordering of the cosmid sequences.
View on ASMUSA
Occurrence of deletions, associated with genetic instability in Streptomyces ambofaciens, is independent of the linearity of the chromosomal DNA
TLDR
Additional deletion events were detected in 11 mutants among the 13 strains isolated, demonstrating that circular chromosomes do not correspond to a stabilization of the chromosome structure and that the occurrence of deletion could be independent of the presence of chromosomal ends.
View on ASMUSA
The unstable region of Streptomyces ambofaciens includes 210 kb terminal inverted repeats flanking the extremities of the linear chromosomal DNA
TLDR
Physical maps of the chromosomes of three strains of Streptomyces ambofaciens were constructed by ordering AseI fragments generated from the genomic DNA as a single linear chromosome of about 8 Mb, which corresponds to the longest terminal inverted repeats so far characterized.
View on Wiley
Evolution of the terminal regions of the Streptomyces linear chromosome.
TLDR
It is speculated that a gradient of recombination rate toward the extremities is the force driving the exclusion of essential genes from the terminal regions (i.e., chromosome compartmentalization) and generating a fast gene turnover for strong adaptation capabilities.
View on PubMed
Involvement of AlpV, a New Member of the Streptomyces Antibiotic Regulatory Protein Family, in Regulation of the Duplicated Type II Polyketide Synthase alp Gene Cluster in Streptomyces ambofaciens
ABSTRACT A type II polyketide synthase gene cluster located in the terminal inverted repeats of Streptomyces ambofaciens ATCC 23877 was shown to be responsible for the production of an orange pigment…
View on ASMUSA
Diversity and Mobility of Integrative and Conjugative Elements in Bovine Isolates of Streptococcusagalactiae, S. dysgalactiae subsp. dysgalactiae, and S. uberis
TLDR
These ICEs could thus also be a vehicle for horizontal gene transfer between streptococci of animal and/or human origin and their association with macrolide, lincosamide, and tetracycline resistance.
View on Publisher
New insights into the genetic instability of streptomyces.
TLDR
The high level of genetic instability in Streptomyces ambofaciens is related to large scale DNA rearrangements (deletions and DNA amplifications) which occur within a 2 Mb chromosomal region, which suggests that the unstable region of StrePTomyces includes the replication terminus, and that chromosomal instability isrelated to the termination process.
View on PubMed
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License