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Signaling Pathways for PC12 Cell Differentiation: Making the Right Connections
TLDR
The Connections Map for PC12 Cell Differentiation brings into focus the complex array of specific cellular responses that rely on canonical signal transduction systems.
K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells
K-252a, a kinase inhibitor isolated from the culture broth of Nocardiopsis sp., selectively inhibits the actions of nerve growth factor (NGF) on PC 12 cells. At a concentration of 200 nM, K-252a
Regulation of the differentiation of PC12 pheochromocytoma cells.
The PC12 clone, developed from a pheochromocytoma tumor of the rat adrenal medulla, has become a premiere model for the study of neuronal differentiation. When treated in culture with nanomolar
Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity.
TLDR
The results suggest that T cell intervention in the injured CNS might prove to be a useful means of promoting post-injury CNS maintenance and recovery, possibly via supply of NTs and other factors.
Protein kinase C-epsilon plays a role in neurite outgrowth in response to epidermal growth factor and nerve growth factor in PC12 cells.
TLDR
An important role for PKC-epsilon is suggested in neurite outgrowth in PC12 cells, probably via activation of the MAPK pathway.
Nerve growth factor–endothelial cell interaction leads to angiogenesis in vitro and in vivo
TLDR
The data indicate that NGF may play an important role in blood vessel formation in the nervous system and in several pathological processes, including tumors and inflammatory diseases.
Cell cycle‐specific action of nerve growth factor in PC12 cells: differentiation without proliferation.
TLDR
The results indicated that serum starvation resulted in synchronisation of the cultures and that NGF action may be cell cycle‐specific, and illustrate that measurements of NGF effects on specific components in the signal transduction pathway may be confounded by the use of exponentially‐growing cultures.
cAMP Response Element-Binding Protein (CREB): A Possible Signaling Molecule Link in the Pathophysiology of Schizophrenia
TLDR
Findings suggest a link between CREB and the pathophysiology of schizophrenia, and Targeting research and drug development on CREB could potentially accelerate the development of novel medications against schizophrenia.
Multimodal Neuroprotection Induced by PACAP38 in Oxygen–Glucose Deprivation and Middle Cerebral Artery Occlusion Stroke Models
TLDR
In vitro and in vivo results propose that PACAP exhibits neuroprotective effects in cerebral ischemia by three mechanisms: a direct one, mediated by PACAP receptors, and two indirect, induced by neurotrophin release, activation of the trkB receptors and attenuation of neuronal growth inhibitory signaling molecules p75NTR and Nogo receptor.
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