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Signaling Pathways for PC12 Cell Differentiation: Making the Right Connections
A key issue in signal transduction is how signaling pathways common to many systems—so-called canonical signaling cassettes—integrate signals from molecules having a wide spectrum of activities, suchExpand
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K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells
K-252a, a kinase inhibitor isolated from the culture broth of Nocardiopsis sp., selectively inhibits the actions of nerve growth factor (NGF) on PC 12 cells. At a concentration of 200 nM, K-252aExpand
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Regulation of the differentiation of PC12 pheochromocytoma cells.
The PC12 clone, developed from a pheochromocytoma tumor of the rat adrenal medulla, has become a premiere model for the study of neuronal differentiation. When treated in culture with nanomolarExpand
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Protein kinase C-epsilon plays a role in neurite outgrowth in response to epidermal growth factor and nerve growth factor in PC12 cells.
In this study, we examined the role of specific protein kinase C (PKC) isoforms in the differentiation of PC12 cells in response to nerve growth factor (NGF) and epidermal growth factor (EGF). PC12Expand
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Production of neurotrophins by activated T cells: implications for neuroprotective autoimmunity.
Neurotrophins (NTs) promote neuronal survival and maintenance during development and after injury. However, their role in the communication between the nervous system and the immune system is not yetExpand
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Nerve growth factor–endothelial cell interaction leads to angiogenesis in vitro and in vivo
Nerve growth factor (NGF) has important functions during embryonic development and on various tissues and organs under normal and pathological conditions during the extrauterine life. RT‐PCR analysisExpand
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Proline-rich Akt substrate of 40kDa (PRAS40): a novel downstream target of PI3k/Akt signaling pathway.
Modifications in signaling of the proline-rich Akt substrate of 40-kDa (PRAS40) pathway is implicated in type 2 diabetes and melanoma. PRAS40 is known for its ability to regulate the mammalian targetExpand
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Structural determinants of the selectivity of KTS‐disintegrins for the α1β1 integrin
KTS‐disintegrins are a subfamily of short monomeric disintegrins that are potent and selective inhibitors of α1β1 integrin. The amino acid sequence of the new KTS‐disintegrin, viperistatin, differsExpand
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Cell cycle‐specific action of nerve growth factor in PC12 cells: differentiation without proliferation.
PC12 cells were manipulated in such a way as to permit the study of differentiation‐specific responses independently from proliferative responses. Cells were starved for serum then exposed to nerveExpand
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Ca2+-activated K+ Channels in Human Leukemic Jurkat T Cells
Previous studies have demonstrated the presence of apamin-sensitive, small-conductance Ca2+-activated K+ currents in human leukemic Jurkat T cells. Using a combined cDNA and reverseExpand
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