Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity
- J. Casal, P. Lawrence, G. Struhl
- BiologyDevelopment
- 15 November 2006
It is found that either Ds or Ft is required in cells that send information and it is shown that both Ds and Ft are required in the responding cells, suggesting how polarity may be propagated by Ds-Ft heterodimers acting as bridges between cells.
Planar cell polarity: one or two pathways?
- P. Lawrence, G. Struhl, J. Casal
- BiologyNature reviews genetics
- 12 June 2007
It is argued that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and concluded that there are (at least) two independently acting processes in the PCP field.
Segmentation and specification of the Drosophila mesoderm.
- N. Azpiazu, P. Lawrence, J. Vincent, M. Frasch
- BiologyGenes & Development
- 15 December 1996
The regulation of two mesodermal genes: bagpipe (bap) and serpent (srp) are focused on, which defines the anlagen of the visceral musculature of the midgut, and serpent, which marks the anbodies of the fat body, respectively.
Cell interactions and planar polarity in the abdominal epidermis of Drosophila
- P. Lawrence, J. Casal, G. Struhl
- BiologyDevelopment
- 1 October 2004
A model that builds on an earlier picture of a gradient of X, the vector of which specifies planar polarity and depends on two cadherin proteins, Dachsous and Fat, argues that Stan must be present in both cells being compared and acts as a conduit between them for the transfer of information.
Induction across germ layers in Drosophila mediated by a genetic cascade
- Karin Immerglück, P. Lawrence, M. Bienz
- BiologyCell
- 27 July 1990
Morphogens, Compartments, and Pattern: Lessons from Drosophila?
- P. Lawrence, G. Struhl
- BiologyCell
- 28 June 1996
Measuring dimensions: the regulation of size and shape.
- S. J. Day, P. Lawrence
- BiologyDevelopment
- 15 July 2000
A hypothesis that the local steepness of a morphogen gradient is a measure of length in one axis, a measure that is used to determine whether there will be net growth or not is discussed.
Developmental Compartments and Planar Polarity in Drosophila
- J. Casal, G. Struhl, P. Lawrence
- BiologyCurrent Biology
- 23 July 2002
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