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Transplantation of Nanoparticle Transfected Skeletal Myoblasts Overexpressing Vascular Endothelial Growth Factor-165 for Cardiac Repair
Background— We investigated the feasibility and efficacy of polyethylenimine (PEI) based human vascular endothelial growth factor-165 (hVEGF165) gene transfer into human skeletal myoblasts (HSM) for… Expand
Normal myoblast injections provide genetic treatment for murine dystrophy
A treatment has been developed to alleviate muscle weakness in murine dystrophy. Cultured myoblasts from genetically normal mouse embryos were injected into the right soleus of 20‐day‐old normal or… Expand
Angiomyogenesis for cardiac repair using human myoblasts as carriers of human vascular endothelial growth factor
This study investigated the potential of human skeletal myoblast carrying human VEGF165 for angiomyogenesis for cardiac repair. A porcine heart model of chronic infarction was created in 18 female… Expand
Histoincompatible myoblast injection improves muscle structure and function of dystrophic mice.
First human myoblast transfer therapy continues to show dystrophin after 6 years.
Cell Transplantation as an Experimental Treatment for Duchenne Muscular Dystrophy
The feasibility, safety, and efficacy of myoblast transfer therapy (MTT) were assessed in an experimental lower body treatment (LBT) involving 32 Duchenne muscular dystrophy (DMD) boys aged 6-14 yr,… Expand
Electrophysiologic differences between mouse extensor digitorum longus and soleus
Miniature end-plate potentials (MEPPs) and indirectly elicited action potentials were recorded in vivo at 37 degrees C from surface fibers of the fast-twitch extensor digitorum longus (EDL) and the… Expand
Myoblast Transfer: The Therapy For Muscular Dystrophy
- P. Law
- 1 November 2004
This text is devoted to the development of a treatment for human muscular dystrophies called myoblast transfer therapy. Written by the pioneer of the procedure, the text presents a review with… Expand
Ultrastructural changes in muscle and motor end-plate of the dystrophic mouse
A comparative study of dystrophic mice (C57BL/6J-dy2J) and normal littermates, 6 to 9 months old, has revealed numerous ultrastructural changes in the dystrophic soleus. Vacuoles, swollen… Expand
Improved angiogenic response in pig heart following ischaemic injury using human skeletal myoblast simultaneously expressing VEGF165 and angiopoietin‐1
To achieve angiogenic interaction between VEGF165 and angiopoietin‐1 (Ang‐1) using a novel adenoviral bicistronic vector (Ad‐Bic) encoding the two factors and delivered ex vivo using sex‐mismatched… Expand