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Consensus statement for inert gas washout measurement using multiple- and single- breath tests
Inert gas washout tests, performed using the single- or multiple-breath washout technique, were first described over 60 years ago. As measures of ventilation distribution inhomogeneity, they offerExpand
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Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease
Interleukin-8 (IL-8) activates neutrophils via the chemokine receptors CXCR1 and CXCR2. However, the airways of individuals with cystic fibrosis are frequently colonized by bacterial pathogens,Expand
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European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia
The diagnosis of primary ciliary dyskinesia is often confirmed with standard, albeit complex and expensive, tests. In many cases, however, the diagnosis remains difficult despite the array ofExpand
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α1-Antitrypsin inhalation reduces airway inflammation in cystic fibrosis patients
The airways of cystic fibrosis (CF) patients are characterised by neutrophils that release high amounts of elastase overwhelming the local antiprotease shield. Inhalation of α1-antitrypsin (AAT) mayExpand
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High rhinovirus burden in lower airways of children with cystic fibrosis.
BACKGROUND Rhinovirus (RV)-induced pulmonary exacerbations are common in cystic fibrosis (CF) and have been associated with impaired virus clearance by the CF airway epithelium in vitro. Here, weExpand
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Impact of Sepsis on Neurodevelopmental Outcome in a Swiss National Cohort of Extremely Premature Infants
OBJECTIVE: Neonatal sepsis causes high mortality and morbidity in preterm infants, but less is known regarding the long-term outcome after sepsis. This study aimed to determine the impact of sepsisExpand
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Clonal analysis of Inquilinus limosus isolates from six cystic fibrosis patients and specific serum antibody response.
Inquilinus limosus is a novel Gram-negative bacterium of the subdivision alpha-Proteobacteria recently found in the airways of patients with cystic fibrosis (CF). Here, the authors report on theExpand
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A Realistic Validation Study of a New Nitrogen Multiple-Breath Washout System
Background For reliable assessment of ventilation inhomogeneity, multiple-breath washout (MBW) systems should be realistically validated. We describe a new lung model for in vitro validation underExpand
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Lung Volume, Breathing Pattern and Ventilation Inhomogeneity in Preterm and Term Infants
Background Morphological changes in preterm infants with bronchopulmonary dysplasia (BPD) have functional consequences on lung volume, ventilation inhomogeneity and respiratory mechanics. AlthoughExpand
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Air pollution during pregnancy and lung development in the child.
Air pollution exposure has increased extensively in recent years and there is considerable evidence that exposure to particulate matter can lead to adverse respiratory outcomes. The health impacts ofExpand
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