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Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies
TLDR
Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious,…
- D. Pinto, M. J. Orwat, P. Lam
- Chemistry, BiologyJournal of medicinal chemistry
- 3 October 2007
TLDR
Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors.
TLDR
Discovery of 1-[3-(aminomethyl)phenyl]-N-3-fluoro-2'-(methylsulfonyl)-[1,1'-biphenyl]-4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC423), a highly potent, selective, and orally bioavailable…
- D. Pinto, M. J. Orwat, P. Lam
- Chemistry, BiologyJournal of medicinal chemistry
- 24 January 2001
TLDR
Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.
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Preclinical Pharmacokinetic and Metabolism of Apixaban, a Potent and Selective Factor Xa Inhibitor.
- K. He, B. He, S. Grossman
- Biology, Medicine
- 16 November 2006
TLDR
Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor
- K. He, J. Luettgen, S. Grossman
- Biology, ChemistryEuropean Journal of Drug Metabolism and…
- 2 April 2011
TLDR
In vitro anti-human immunodeficiency virus (HIV) activity of XM323, a novel HIV protease inhibitor
- M. Otto, C. Reid, D. Winslow
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 December 1993
TLDR
Discovery of a Parenteral Small Molecule Coagulation Factor XIa Inhibitor Clinical Candidate (BMS-962212).
- D. Pinto, M. J. Orwat, W. R. Ewing
- Biology, MedicineJournal of medicinal chemistry
- 17 November 2017
TLDR
Nonpeptide cyclic cyanoguanidines as HIV-1 protease inhibitors: synthesis, structure-activity relationships, and X-ray crystal structure studies.
- P. Jadhav, F. Woerner, C. Chang
- Chemistry, BiologyJournal of medicinal chemistry
- 23 April 1998
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