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Hepatic Endothelial CCL25 Mediates the Recruitment of CCR9+ Gut-homing Lymphocytes to the Liver in Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC), a chronic inflammatory liver disease characterized by progressive bile duct destruction, develops as an extra-intestinal complication of inflammatory bowelExpand
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MAdCAM‐1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM‐1 in chronic inflammatory liver disease)
Mucosal addressin cell adhesion molecule (MAdCAM‐1) plays a pivotal role in T‐lymphocyte homing to the gut. Given the strong association between the autoimmune liver diseases primary sclerosingExpand
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An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
The exit of antigen-presenting cells and lymphocytes from inflamed skin to afferent lymph is vital for the initiation and maintenance of dermal immune responses. How such an exit is achieved and howExpand
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CXC Chemokine Ligand 16 Promotes Integrin-Mediated Adhesion of Liver-Infiltrating Lymphocytes to Cholangiocytes and Hepatocytes within the Inflamed Human Liver1
Lymphocyte recruitment to the liver is critical for viral clearance in acute hepatitis and in the pathogenesis of chronic inflammatory liver disease when persistent chronic inflammation leads toExpand
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Monocyte subsets in human liver disease show distinct phenotypic and functional characteristics
Liver fibrosis is a wound healing response to chronic liver injury and inflammation in which macrophages and infiltrating monocytes participate in both the development and resolution phase. InExpand
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An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium
Johnson et al. 2006. J. Exp. Med. doi:10.1084/jem.20051759[OpenUrl][1][Abstract/FREE Full Text][2] [1]:Expand
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CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow.
T cells infiltrating the inflamed liver express high levels of CXCR 3 and show enhanced migration to CXCR 3 ligands in chemotactic assays. Moreover, CXCR 3 ligands are up-regulated on hepaticExpand
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Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver
Regulatory T cells (Tregs) are found at sites of chronic inflammation where they mediate bystander and Ag-specific suppression of local immune responses. However, little is known about the molecularExpand
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Vascular adhesion protein-1 mediates adhesion and transmigration of lymphocytes on human hepatic endothelial cells.
Vascular adhesion protein-1 (VAP-1) is an amine oxidase and adhesion receptor that is expressed by endothelium in the human liver. The hepatic sinusoids are perfused by blood at low flow rates, andExpand
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Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease
Primary sclerosing cholangitis is strongly linked to inflammatory bowel disease, but any model to explain the development of primary sclerosing cholangitis must take into account the fact that itExpand
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