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Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.
Bone morphogenetic protein-4 (BMP-4) is a member of the TGF-beta superfamily of polypeptide signaling molecules, closely related to BMP-2 and to Drosophila decapentaplegic (DPP). To elucidate theExpand
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PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.
It has been proposed that the Xenopus homeobox gene, XlHbox8, is involved in endodermal differentiation during pancreatic and duodenal development (Wright, C.V.E., Schnegelsberg, P. and De Robertis,Expand
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A dermal niche for multipotent adult skin-derived precursor cells
A fundamental question in stem cell research is whether cultured multipotent adult stem cells represent endogenous multipotent precursor cells. Here we address this question, focusing on SKPs, aExpand
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HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth.
The division, differentiation, and function of stem cells and multipotent progenitors are influenced by complex signals in the microenvironment, including oxygen availability. Using a geneticExpand
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Mouse embryonic germ (EG) cell lines: transmission through the germline and differences in the methylation imprint of insulin-like growth factor 2 receptor (Igf2r) gene compared with embryonic stem
Primordial germ cells of the mouse cultured on feeder layers with leukemia inhibitory factor, Steel factor and basic fibroblast growth factor give rise to cells that resemble undifferentiatedExpand
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Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor
THERE are two major angiotensin II receptor isoforms, AT1 and AT2. AT1 mediates the well-known pressor and mitogenic effects of angiotensin II (refs 1-5), but the signalling mechanism andExpand
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The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate.
The neural crest is a migratory cell population that gives rise to multiple cell types in the vertebrate embryo. The intrinsic determinants that segregate neural crest cells from multipotentialExpand
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The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.
Klf4 (formerly GKLF) is a zinc-finger transcription factor expressed in the epithelia of the skin, lungs, gastrointestinal tract and several other organs. In vitro studies have suggested that Klf4Expand
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Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin.
Matrix metalloproteinases (MMPs) classically have been implicated in basement membrane destruction associated with late-stage tumor cell invasion and metastasis. However, recent studies haveExpand
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Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo.
Critical to our understanding of the developmental potential of stem cells and subsequent control of their differentiation in vitro and in vivo is a thorough understanding of the genes that controlExpand
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