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Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver.
Obstructive sleep apnea (OSA) causes chronic intermittent hypoxia (CIH) during sleep. OSA is associated with nonalcoholic steatohepatitis (NASH) in obese individuals and may contribute to progressionExpand
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Topical paromomycin with or without gentamicin for cutaneous leishmaniasis.
BACKGROUND There is a need for a simple and efficacious treatment for cutaneous leishmaniasis with an acceptable side-effect profile. METHODS We conducted a randomized, vehicle-controlled phase 3Expand
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Tracheal and neck position influence upper airway airflow dynamics by altering airway length.
Upper airway obstruction during sleep is characterized by inspiratory airflow limitation and reductions in maximal inspiratory airflow (VImax). To determine how mechanical factors modulate VImax, weExpand
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WR279,396, a Third Generation Aminoglycoside Ointment for the Treatment of Leishmania major Cutaneous Leishmaniasis: A Phase 2, Randomized, Double Blind, Placebo Controlled Study
Background Cutaneous leishmaniasis (CL) is a disfiguring disease that confronts clinicians with a quandary: leave patients untreated or engage in a complex or toxic treatment. Topical treatment of CLExpand
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Preparative Separation of Indole Alkaloids from the Rind of Picralima nitida (Stapf) T. Durand & H. Durand by pH‐Zone‐Refining Countercurrent Chromatography
Abstract Picralima nitida alkaloids have been shown to possess in vitro antimalarial activity comparable to the clinical antimalarial chloroquine and quinine. The in vitro IC50 values for theseExpand
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Enhanced intestinal absorption of an RGD peptide from water-in-oil microemulsions of different composition and particle size
Abstract The fibrinogen receptor antagonist SK&F 106760 is a water-soluble tetrapeptide (Mr634) with very low oil/water partitioning and membrane permeability. Thus, the intraduodenal bioavailabilityExpand
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Synthesis of analogs of L-valacyclovir and determination of their substrate activity for the oligopeptide transporter in Caco-2 cells.
L-Valacyclovir, a prodrug of acyclovir, is a substrate for the peptide transporter (PepT1) in the intestinal mucosa, which accounts for its higher than expected oral bioavailability. The substrateExpand
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Impact of interrupted leptin pathways on ventilatory control.
Leptin deficiency in ob/ob mice produces marked depression of the hypercapnic ventilatory response, particularly during sleep. We now extend our previous findings to determine whether 1) leptinExpand
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Exploitation of the Intestinal Oligopeptide Transporter to Enhance Drug Absorption
AbstractStudies of the mechanisms involved in the transport of di- and tri-peptides by the intestinal oligopeptide transporter suggest a process which involves proton-dependent uptake at the apicalExpand
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