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Objective measurement of patterns of nasal CPAP use by patients with obstructive sleep apnea.
TLDR
Although the majority (60%) of patients claimed to use CPAP nightly, only 16 of 35 patients met criteria for regular use, defined by at least 4 h of CPAP administered on 70% of the days monitored, and these 16 patients had more years of education, and were more likely to work in professional occupations. Expand
Leptin prevents respiratory depression in obesity.
TLDR
The results suggest that leptin can prevent respiratory depression in obesity, but a deficiency in central nervous system leptin levels or activity may induce hypoventilation and the Pickwickian syndrome in some obese subjects. Expand
The hypotonic upper airway in obstructive sleep apnea: role of structures and neuromuscular activity.
TLDR
It is concluded that the hypotonic upper airway becomes most collapsible by the third breath after an abrupt decrease in PN, regardless of sleep stage and despite an increase in genioglossus-muscle activity. Expand
Weight loss in mildly to moderately obese patients with obstructive sleep apnea.
TLDR
Moderate weight loss alone can alleviate sleep apnea, improve sleep architecture, and decrease daytime hypersomnolence. Expand
Direct hypoglossal nerve stimulation in obstructive sleep apnea.
TLDR
Direct HG nerve stimulation below the arousal threshold can improve airflow in patients with obstructive sleep apnea. Expand
Upper airway collapsibility in snorers and in patients with obstructive hypopnea and apnea.
TLDR
Differences in upper airway collapsibility distinguish among groups of normal subjects who snore and patients with periodic hypopneas and apneas, and suggest that small differences in collapsibility along a continuum are associated with reduced airflow and altered changes in pattern of breathing. Expand
Effect of weight loss on upper airway collapsibility in obstructive sleep apnea.
TLDR
It is concluded that weight loss is associated with decreases in upper airway collapsibility in obstructiveSleep apnea, and that the resolution of sleep apnea depends on the absolute level to which Pcrit falls. Expand
Modeling hypersomnolence in sleep-disordered breathing. A novel approach using survival analysis.
TLDR
It is suggested that AHI, nocturnal hypoxemia, and sleep fragmentation are independent determinants of hypersomnolence in SDB. Expand
Physiologic manifestations of human anaphylaxis.
TLDR
Standard therapy with epinephrine and fluids did not immediately reverse either the hemodynamic or the respiratory abnormalities in the two subjects with the most severe anaphylactic shock, and Hemodynamic recovery was gradual and did not seem directly related to any specific therapeutic intervention. Expand
Induction of upper airway occlusion in sleeping individuals with subatmospheric nasal pressure.
TLDR
The data demonstrate that the normal human upper airway during sleep is characterized by a negative Pcrit and that occlusion may be induced when nasal pressure is decreased below this Pcrit. Expand
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