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Mutagenicity of quinones: pathways of metabolic activation and detoxification.
- P. L. Chesis, D. E. Levin, M. Smith, L. Ernster, B. Ames
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 March 1984
The complexity of metabolic pathways involved in the mutagenicity of quinones, a class of compounds widely distributed in nature, are shown, including a cytochrome P-450-dependent reaction, whereas danthron was converted to a highly mutagenic metabolite.
N-(3-[18F]fluoropropyl)-N-nordiprenorphine: synthesis and characterization of a new agent for imaging opioid receptors with positron emission tomography.
The high specific binding demonstrated by the N-fluoroalkyl compounds indicates that it may be useful for in vivo imaging of opioid receptors with positron emission tomography.
Sex-dependent differences in N-(3-[18F]fluoropropyl)-N-nordiprenorphine biodistribution and metabolism.
- P. L. Chesis, L. Griffeth, C. J. Mathias, M. Welch
- Biology, ChemistryJournal of nuclear medicine : official…
- 1 February 1990
It is demonstrated that the possibility of sex-dependent metabolism must be considered when the rat is employed to screen new radiopharmaceuticals because female rats produce a metabolite that both crosses the blood-brain barrier and exhibits opioid receptor-specific binding superior to that of the parent compound.
Synthesis and in vitro characterization of fluorinated U-50488 analogs for PET studies of kappa opioid receptors.
Comparison of bromo- and iodoalkyl triflates for 18F-radiolabeling of amines.