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Mutagenicity of quinones: pathways of metabolic activation and detoxification.
TLDR
The complexity of metabolic pathways involved in the mutagenicity of quinones, a class of compounds widely distributed in nature, are shown, including a cytochrome P-450-dependent reaction, whereas danthron was converted to a highly mutagenic metabolite.
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N-(3-[18F]fluoropropyl)-N-nordiprenorphine: synthesis and characterization of a new agent for imaging opioid receptors with positron emission tomography.
TLDR
The high specific binding demonstrated by the N-fluoroalkyl compounds indicates that it may be useful for in vivo imaging of opioid receptors with positron emission tomography.
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Sex-dependent differences in N-(3-[18F]fluoropropyl)-N-nordiprenorphine biodistribution and metabolism.
TLDR
It is demonstrated that the possibility of sex-dependent metabolism must be considered when the rat is employed to screen new radiopharmaceuticals because female rats produce a metabolite that both crosses the blood-brain barrier and exhibits opioid receptor-specific binding superior to that of the parent compound.
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Synthesis and in vitro characterization of fluorinated U-50488 analogs for PET studies of kappa opioid receptors.
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Comparison of bromo- and iodoalkyl triflates for 18F-radiolabeling of amines.
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