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Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression
TLDR
These findings provide the first evidence that mGluR2/3 is elevated in the PFC in MDD and demonstrates that these receptors are promising targets for the discovery of novel antidepressants.
Severe Illness Associated with Reported Use of Synthetic Cannabinoids - Mississippi, April 2015.
TLDR
The Mississippi State Department of Health and CDC initiated an investigation to better characterize the outbreak, identify risk factors associated with severe illness, and prevent additional illnesses and deaths.
Illicit bath salts: not for bathing.
TLDR
Clinicians should be aware that these designer drugs are not detected with common immunoassay drug screens, and should not be surprised if these substances are associated with psychosis, self harm, and death.
Cardiac toxicity of some echinocandin antifungals
TLDR
Assessment of cardiac toxicity associated with the echinocandins found mean concentrations of ANID and CASP were associated with statistically significant decreases in left ventricular contractility at concentrations that may be achievable in humans after peripheral administration, while MICA caused no change.
Oligodendrocyte morphometry and expression of myelin - Related mRNA in ventral prefrontal white matter in major depressive disorder.
TLDR
Altered expression of four myelin genes and CNPase protein suggests a mechanism for the degeneration of cortical axons and dysfunctional maturation of oligodendrocytes in MDD.
Decreased expression of Freud-1/CC2D1A, a transcriptional repressor of the 5-HT1A receptor, in the prefrontal cortex of subjects with major depression.
TLDR
Reduced protein expression of Freud-1 in MDD subjects may reflect dysregulation of this transcription factor, which may contribute to the altered regulation of 5-HT(1A) receptors observed in subjects with MDD.
Characterization of the development of renal injury in Type-1 diabetic Dahl salt-sensitive rats.
TLDR
Results indicate that SS rats treated with STZ develop hyperfiltration and progressive proteinuria and display renal histological lesions characteristic of those seen in patients with diabetic nephropathy, which may be useful to study signaling pathways and mechanisms that play a role in the progression of diabetes-induced renal disease.
Suspected Pediatric Ingestions: Effectiveness of Immunoassay Screens vs. Gas Chromatography/Mass Spectroscopy in the Detection of Drugs and Chemicals
TLDR
Analysis by GC/MS offers the clinician a more comprehensive view into the exposure of the pediatric patient presenting with an unknown chemical ingestion, as compared to results obtained by immunoassay testing.
Loss of Arhgef11 in the Dahl Salt-Sensitive Rat Protects Against Hypertension-Induced Renal Injury
TLDR
In vivo phenotyping coupled with a multi-omics approach provides strong evidence that increased Arhgef11 expression in the Dahl SS rat leads to actin cytoskeleton-mediated changes in cell morphology and cell function that promote kidney injury, hypertension, and decline in kidney function.
Allopregnanolone Reinstates Tyrosine Hydroxylase Immunoreactive Neurons and Motor Performance in an MPTP-Lesioned Mouse Model of Parkinson's Disease
TLDR
It is demonstrated that allopregnanolone promotes the restoration of tyrosine hydroxylase immunoreactive neurons and total cells in the nigrostriatal tract, improves the motor performance in MPTP-treated mice, and may serve as a therapeutic strategy for Parkinson's disease.
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