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Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia
Ablation of a gene controlling fat breakdown can protect mice from cancer-associated uncontrolled loss of fat and muscle. 10.1126/science.1198973 Cachexia is a multifactorial wasting syndrome mostExpand
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LIN41 Post-transcriptionally Silences mRNAs by Two Distinct and Position-Dependent Mechanisms.
The RNA-binding protein (RBP) LIN41, also known as LIN-41 or TRIM71, is a key regulator of animal development, but its physiological targets and molecular mechanism of action are largely elusive.Expand
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Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice
Nonalcoholic fatty liver disease (NAFLD) is characterized by triglyceride (TG) accumulation and endoplasmic reticulum (ER) stress. Because fatty acids (FAs) may trigger ER stress, we hypothesizedExpand
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An essential role for maternal control of Nodal signaling
Growth factor signaling is essential for pattern formation, growth, differentiation, and maintenance of stem cell pluripotency. Nodal-related signaling factors are required for axis formation andExpand
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Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition
RNA-binding proteins regulate all aspects of RNA metabolism. Their association with RNA is mediated by RNA-binding domains, of which many remain uncharacterized. A recently reported example is theExpand
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cncRNAs: Bi-functional RNAs with protein coding and non-coding functions
For many decades, the major function of mRNA was thought to be to provide protein-coding information embedded in the genome. The advent of high-throughput sequencing has led to the discovery ofExpand
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Dorsal activity of maternal squint is mediated by a non-coding function of the RNA
Despite extensive study, the earliest steps of vertebrate axis formation are only beginning to be elucidated. We previously showed that asymmetric localization of maternal transcripts of theExpand
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Protein kinase G confers survival advantage to Mycobacterium tuberculosis during latency-like conditions
Protein kinase G (PknG), a thioredoxin-fold–containing eukaryotic-like serine/threonine protein kinase, is a virulence factor in Mycobacterium tuberculosis, required for inhibition of phagolysosomalExpand
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Conservation defines functional motifs in the squint/nodal-related 1 RNA dorsal localization element
RNA localization is emerging as a general principle of sub-cellular protein localization and cellular organization. However, the sequence and structural requirements in many RNA localization elementsExpand
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Translational co-regulation of a ligand and inhibitor by a conserved RNA element
Abstract In many organisms, transcriptional and post-transcriptional regulation of components of pathways or processes has been reported. However, to date, there are few reports of translationalExpand
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