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- Publications
- Influence
Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia
- S. K. Das, S. Eder, +12 authors Gerald Hoefler
- Biology, Medicine
- Science
- 8 July 2011
Ablation of a gene controlling fat breakdown can protect mice from cancer-associated uncontrolled loss of fat and muscle. 10.1126/science.1198973 Cachexia is a multifactorial wasting syndrome most… Expand
LIN41 Post-transcriptionally Silences mRNAs by Two Distinct and Position-Dependent Mechanisms.
- Florian Aeschimann, P. Kumari, +4 authors H. Grosshans
- Biology, Medicine
- Molecular cell
- 2 February 2017
The RNA-binding protein (RBP) LIN41, also known as LIN-41 or TRIM71, is a key regulator of animal development, but its physiological targets and molecular mechanism of action are largely elusive.… Expand
Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice
- C. Fuchs, T. Claudel, +9 authors M. Trauner
- Biology, Medicine
- Hepatology
- 1 July 2012
Nonalcoholic fatty liver disease (NAFLD) is characterized by triglyceride (TG) accumulation and endoplasmic reticulum (ER) stress. Because fatty acids (FAs) may trigger ER stress, we hypothesized… Expand
An essential role for maternal control of Nodal signaling
- P. Kumari, P. Gilligan, +4 authors K. Sampath
- Biology, Medicine
- eLife
- 10 September 2013
Growth factor signaling is essential for pattern formation, growth, differentiation, and maintenance of stem cell pluripotency. Nodal-related signaling factors are required for axis formation and… Expand
Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition
- P. Kumari, Florian Aeschimann, +8 authors Rafal Ciosk
- Biology, Medicine
- Nature Communications
- 19 April 2018
RNA-binding proteins regulate all aspects of RNA metabolism. Their association with RNA is mediated by RNA-binding domains, of which many remain uncharacterized. A recently reported example is the… Expand
cncRNAs: Bi-functional RNAs with protein coding and non-coding functions
- P. Kumari, K. Sampath
- Biology, Medicine
- Seminars in cell & developmental biology
- 1 December 2015
For many decades, the major function of mRNA was thought to be to provide protein-coding information embedded in the genome. The advent of high-throughput sequencing has led to the discovery of… Expand
Dorsal activity of maternal squint is mediated by a non-coding function of the RNA
- Shimin Lim, P. Kumari, P. Gilligan, H. Quach, S. Mathavan, K. Sampath
- Biology, Medicine
- Development
- 15 August 2012
Despite extensive study, the earliest steps of vertebrate axis formation are only beginning to be elucidated. We previously showed that asymmetric localization of maternal transcripts of the… Expand
Protein kinase G confers survival advantage to Mycobacterium tuberculosis during latency-like conditions
- M. Khan, Ashima Bhaskar, +7 authors V. K. Nandicoori
- Biology, Medicine
- The Journal of Biological Chemistry
- 18 August 2017
Protein kinase G (PknG), a thioredoxin-fold–containing eukaryotic-like serine/threonine protein kinase, is a virulence factor in Mycobacterium tuberculosis, required for inhibition of phagolysosomal… Expand
Conservation defines functional motifs in the squint/nodal-related 1 RNA dorsal localization element
- P. Gilligan, P. Kumari, S. Lim, Albert Cheong, A. Chang, K. Sampath
- Biology, Medicine
- Nucleic acids research
- 10 December 2010
RNA localization is emerging as a general principle of sub-cellular protein localization and cellular organization. However, the sequence and structural requirements in many RNA localization elements… Expand
Translational co-regulation of a ligand and inhibitor by a conserved RNA element
- A. Zaucker, Agnieszka Nagorska, +9 authors K. Sampath
- Biology, Medicine
- Nucleic acids research
- 20 October 2017
Abstract In many organisms, transcriptional and post-transcriptional regulation of components of pathways or processes has been reported. However, to date, there are few reports of translational… Expand
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