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Polycystin-2 is an intracellular calcium release channel
Polycystin-2, the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease (ADPKD), is the prototypical member of a subfamily of the transient receptor potential (TRP)Expand
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Glycine and GABA receptors in the mammalian retina
Molecular cloning has introduced an unexpected diversity of neurotransmitter receptors. In this study we review the types, the localization and possible synaptic function of the inhibitoryExpand
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The cytosolic N-terminus of presenilin-1 potentiates mouse ryanodine receptor single channel activity.
Ryanodine receptors (RyRs) amplify intracellular Ca(2+) signals by massively releasing Ca(2+) from intracellular stores. Exaggerated chronic Ca(2+) release can trigger cellular apoptosis underlying aExpand
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Diversity of glutamate receptors in the mammalian retina
The main neurotransmitters in the vertebrate retina are glutamate, GABA and glycine. Their localization in the different cell types in the retina is well known. In addition, there exists a number ofExpand
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Immunocytochemical Localization of the Postsynaptic Density Protein PSD-95 in the Mammalian Retina
Synapse-associated proteins are the scaffold for the selective aggregation of ion channels at synapses; they provide the link to cytoskeletal elements and possibly are involved with the regulation ofExpand
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Synaptic clustering of GABAC receptor ρ‐subunits in the rat retina
Polyclonal antibodies which recognize the ρ‐subunits of the GABAC receptor were applied to sections of the rat retina. Strong punctate immunoreactivity was found in the inner plexiform layer (IPL),Expand
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Group I Metabotropic Glutamate Receptors mGluR1α and mGluR5a: Localization in Both Synaptic Layers of the Rat Retina
We examined the distribution of the group I metabotropic glutamate receptors, mGluR1α and mGluR5a, in the adult rat retina and during postnatal development using receptor-specific antisera. InExpand
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Presynaptic and postsynaptic localization of GABAB receptors in neurons of the rat retina
The recently cloned GABAB receptors were localized in rat retina using specific antisera. Immunolabelling was detected in the inner and outer plexiform layers (IPL, OPL), and in a number of cells inExpand
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The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein-protein interaction.
Presenilin-1 (PS1) and presenilin-2 (PS2) form the catalytic core in gamma-secretase complexes and mutations in these proteins result in aberrant cleavage of amyloid precursor protein leading toExpand
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Mitochondrial localization of estrogen receptor β
Estrogen receptors (ERs) are believed to be ligand-activated transcription factors belonging to the nuclear receptor superfamily, which on ligand binding translocate into the nucleus and activateExpand
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