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Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors
The new oral anticoagulants dabigatran, rivaroxaban and apixaban have advantages over warfarin which include no need for laboratory monitoring, less drug–drug interactions and less food‐drugExpand
Diagnosis and treatment of inherited factor X deficiency
  • D. Brown, P. Kouides
  • Medicine
  • Haemophilia : the official journal of the World…
  • 1 November 2008
Patients with moderate–severe FX deficiency may have symptoms similar to that of haemophilia A and B, including haemarthrosis, intracranial haemorrhage, and gastrointestinal bleeding, andotype characterization may offer important clues about clinical prognosis. Expand
Evaluation and management of postpartum hemorrhage: consensus from an international expert panel
Postpartum hemorrhage (PPH) remains one of the leading causes of maternal morbidity and mortality worldwide, although the lack of a precise definition precludes accurate data of the absoluteExpand
Von Willebrand disease and other bleeding disorders in women: consensus on diagnosis and management from an international expert panel.
This consensus is intended to allow physicians to better recognize bleeding disorders as a cause of menorrhagia and consequently offer effective disease-specific therapies. Expand
Multisite management study of menorrhagia with abnormal laboratory haemostasis: a prospective crossover study of intranasal desmopressin and oral tranexamic acid
It is concluded that both medications reduced MBL and improved QOL among females with menorrhagia and abnormal laboratory haemostasis, but TA proved more effective. Expand
Evaluation and management of acute menorrhagia in women with and without underlying bleeding disorders: consensus from an international expert panel.
An international expert panel in obstetrics, gynecology and hematology reached consensus on recommendations regarding the management of acute menorrhagia in women without a diagnosed bleeding disorder, as well as in patients with von Willebrand disease, platelet function disorders and other rare hemostatic disorders. Expand
Gynaecological and obstetrical morbidity in women with type I von Willebrand disease: results of a patient survey
The rationale for ongoing international efforts to increase awareness of type 1 von Willebrand disease as a cause for menorrhagia and to improve the quality of life in females with known vWD is supported. Expand
Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease.
Results show that rVWF was safe and effective in treating bleeds in VWD patients and stabilizes endogenous FVIII : C, which may eliminate the need for rFVIII after the first infusion. Expand
Dabigatran-Induced Gastrointestinal Bleeding in an Elderly Patient with Moderate Renal Impairment
A 66-year-old woman treated with dabigatran for atrial fibrillation developed acute renal failure and upper gastrointestinal bleeding and died 2 months later, illustrating the importance for appropriate patient selection and the need to periodically monitor renal function in elderly patients receiving dabig atran. Expand
Emerging clinical concerns in the ageing haemophilia patient
A review of five comorbidities that uniquely affect older PWH: cardiovascular disease, liver disease, cancer, renal disease and joint disease, which is summarized and potential management approaches are suggested. Expand