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The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism
It is found that CARKL-dependent metabolic reprogramming is required for proper M1- and M2-like macrophage polarization and a rate-limiting requirement for appropriate glucose flux in macrophages polarization is uncovered. Expand
The chemistry of side reactions and byproduct formation in the system NMMO/cellulose (Lyocell process)
Abstract N -Methylmorpholine- N -oxide monohydrate (NMMO) is used as a solvent for direct dissolution of cellulose in industrial fiber-making (Lyocell process). Ideally, Lyocell fiber production per… Expand
Germline antibody recognition of distinct carbohydrate epitopes
It is shown that antibody S25-2 binds several distinct inner-core epitopes of bacterial lipopolysaccharides of LPSs by linking an inherited monosaccharide residue binding site with a subset of complementarity-determining regions (CDRs) of limited flexibility positioned to recognize the remainder of an array of different epitopes. Expand
Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides.
This work reviews the state of the art of these biosynthesis pathways, particularly regarding the enzyme functions involved in the various steps of the biosynthesis of ADP--glycero- -mannoheptose and GDP and provides a comparative genetic analysis ofThe biosynthetic genes in sequenced bacterial genomes. Expand
Classification of isolates from locations in Austria and Yellowstone National Park as Geobacillus tepidamans sp. nov.
- C. Schäffer, William L. Franck, A. Scheberl, P. Kosma, T. McDermott, P. Messner
- Biology, Medicine
- International journal of systematic and…
- 1 November 2004
Two moderately thermophilic, Gram-positive, spore-forming bacteria were isolated from different geographical locations and sources; strain GS5-97(T) from a beet sugar factory in Leopoldsdorf, Lower… Expand
Identification of Two GDP-6-deoxy-d-lyxo-4-hexulose Reductases Synthesizing GDP-d-rhamnose in Aneurinibacillus thermoaerophilus L420-91T *
- B. Kneidinger, M. Graninger, +4 authors P. Messner
- Medicine, Chemistry
- The Journal of Biological Chemistry
- 23 February 2001
Nuclear magnetic resonance spectroscopy was used to identify the structure of the final product of the reaction sequence as GDP-α-d-rhamnose, the first characterization of a GDP-6-deoxy- d-lyxo-4-hexulose reductase. Expand
Occurrence of antibodies against chlamydial lipopolysaccharide in human sera as measured by ELISA using an artificial glycoconjugate antigen.
- L. Brade, H. Brunnemann, +6 authors H. Brade
- Medicine, Biology
- FEMS immunology and medical microbiology
In comparison to the results obtained with sera from blood donors, it became evident that both types of infection result in significant changes in the profile of LPS antibodies. Expand
Two β-Galactosidases from the Human Isolate Bifidobacterium breve DSM 20213: Molecular Cloning and Expression, Biochemical Characterization and Synthesis of Galacto-Oligosaccharides
Two β-galactosidases, β-gal I and β-gal II, from Bifidobacterium breve DSM 20213, which was isolated from the intestine of an infant, were overexpressed in Escherichia coli with co-expression of the… Expand
Biosynthesis Pathway of ADP-l-glycero-β-d-manno-Heptose in Escherichia coli
It has been clearly demonstrated that heptosyltransferases I and II from E. coli accept ADP-l-β-d-heptose and ADP -l,d- heptose as substrates, although the efficiency of the transfer reactions with the d- β-d isomer is markedly reduced. Expand
Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose.
- Andreas Pföstl, S. Zayni, A. Hofinger, P. Kosma, C. Schäffer, P. Messner
- Medicine, Biology
- The Biochemical journal
- 29 January 2008
There is strong evidence that the elucidated biosynthesis pathway of dTDP-alpha-D-Quip3NAc may be valid for LPS (lipopolysaccharide) O-antigen structures and antibiotic precursors. Expand