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Cardiotoxicity of fluoropyrimidines in different schedules of administration: a prospective study
TLDR
The present study supports the toxic effect of 5-FU on the myocardium, which is largely schedule-dependent, whereas a low but finite risk of such toxicity has been observed with oral capecitabine. Expand
Colistin-resistant isolates of Klebsiella pneumoniae emerging in intensive care unit patients: first report of a multiclonal cluster.
TLDR
Selective pressure due to extensive or inadequate colistin use may lead to the emergence ofcolistin resistance among K. pneumoniae isolates, jeopardizing treatment options in the ICU, potentially increasing morbidity and mortality of critically ill patients and necessitating prudent use of colistIn. Expand
Procalcitonin-guided algorithms of antibiotic therapy in the intensive care unit: A systematic review and meta-analysis of randomized controlled trials
TLDR
The implementation of a procalcitonin-based algorithm may reduce antibiotic exposure in critically ill, septic patients without compromising clinical outcomes, but further research is necessary before the wide adoption of this strategy. Expand
Impact of passive humidification on clinical outcomes of mechanically ventilated patients: A meta‐analysis of randomized controlled trials *
TLDR
The available evidence does not support the preferential performance of either passive or active humidifiers in mechanical ventilation patients in terms of ventilator‐associated pneumonia incidence, mortality, or morbidity. Expand
Impact of catheter-related bloodstream infections on the mortality of critically ill patients: A meta-analysis*
TLDR
Presence, as opposed to absence, of CR-BSI is associated with higher mortality in critically ill adult patients, and this finding seems to justify and may enhance efforts to prevent CR- BSI in such patients. Expand
Risk factors for the isolation of multi-drug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa: a systematic review of the literature.
TLDR
It was concluded that acquisition and spread of these micro-organisms appear to be related to a large number of variables, among the most important were deficiencies in the implementation of infection control guidelines and the use of broad-spectrum antibiotics. Expand
Tuberculosis and malignancy.
TLDR
Clinicians need to be aware of the protean manifestations of TB and cancer and maintain a high index of suspicion for simultaneous and/or misleading presentations and to determine if a tuberculous infection, being similar to other chronic infections and inflammatory conditions, may facilitate carcinogenesis. Expand
The effect of the plasminogen activator inhibitor-1 4G/5G polymorphism on the thrombotic risk.
TLDR
The aim is to summarize the variable influence of this polymorphism on thrombotic events in different tissues or organs and explain the underlying mechanisms accounting for these differences. Expand
Aspects of the association between leishmaniasis and malignant disorders.
TLDR
It is concluded that leishmaniasis can directly or indirectly affect the presentation, diagnosis and course of various malignant disorders and it should be considered in the differential diagnosis of malignancies in geographic areas where it is endemic and/or in patients with travel history to these areas. Expand
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