P. Kopec̆ková

Publications182
h-index54
Citations8,253
Highly Influential Citations106
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • J. Kopeček
  • 463 Publications, 21,238 Citations
  • K. Ulbrich
  • 349 Publications, 15,725 Citations
  • B. Říhová
  • 216 Publications, 6,312 Citations
  • R. Duncan
  • 123 Publications, 13,352 Citations
  • Publications
  • Influence
HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action.
The design, synthesis and properties of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers as carriers of anticancer drugs are reviewed. Macromolecular therapeutics based on HPMA copolymers are… Expand
  • 483
  • 10
HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line.
N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer-adriamycin (ADR) conjugate containing lysosomally degradable oligopeptide (GFLG) side chains terminated in ADR was synthesized. The effect of free… Expand
  • 234
  • 6
Targetable HPMA copolymer-adriamycin conjugates. Recognition, internalization, and subcellular fate.
Recognition, internalization, and subcellular trafficking of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer conjugates containing N-acylated galactosamine (GalN) or monoclonal OV-TL16 antibodies… Expand
  • 192
  • 6
HPMA copolymers: origins, early developments, present, and future.
The overview covers the discovery of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers, initial studies on their synthesis, evaluation of biological properties, and explorations of their potential… Expand
  • 409
  • 5
Efficacy of the chemotherapeutic action of HPMA copolymer‐bound doxorubicin in a solid tumor model of ovarian carcinoma
Anticancer activity and main mechanisms of action of free doxorubicin (DOX) and HPMA copolymer‐bound DOX (P(GFLG)‐DOX) were studied in solid tumor mice models of DOX sensitive and resistant human… Expand
  • 160
  • 3
Synthesis and evaluation of water-soluble polymeric bone-targeted drug delivery systems.
Four polymeric bone-targeting conjugates were synthesized based on poly(ethylene glycol) (PEG, two conjugates) and poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA, two conjugates). The well-known… Expand
  • 134
  • 3
Novel pH-sensitive hydrogels with adjustable swelling kinetics.
Novel pH-sensitive hydrogels were synthesized by copolymerization of N,N-dimethylacrylamide, tert.-butylacrylamide, acrylic acid, 4,4'-di(methacryloylamino)azobenzene, and N-alkanoyl,… Expand
  • 131
  • 3
Chronic exposure to HPMA copolymer-bound adriamycin does not induce multidrug resistance in a human ovarian carcinoma cell line.
The influence of free and N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-bound adriamycin (ADR) on the induction of multidrug resistance in the A2780 human ovarian carcinoma cell line was studied… Expand
  • 91
  • 3
Osteotropic Peptide that differentiates functional domains of the skeleton.
HPMA copolymer-d-aspartic acid octapeptide (D-Asp8) conjugates have been found to target the entire skeleton after systemic administration. In a recent study using the ovariectomized rat model of… Expand
  • 74
  • 3
Backbone degradable multiblock N-(2-hydroxypropyl)methacrylamide copolymer conjugates via reversible addition-fragmentation chain transfer polymerization and thiol-ene coupling reaction.
Telechelic water-soluble HPMA copolymers and HPMA copolymer-doxorubicin (DOX) conjugates have been synthesized by RAFT polymerization mediated by a new bifunctional chain transfer agent (CTA) that… Expand
  • 72
  • 3