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Chorismate Mutase-Prephenate Dehydratase from Escherichia coli
The bifunctional P-protein, which plays a central role in Escherichia coli phenylalanine biosynthesis, contains two catalytic domains (chorismate mutase and prephenate dehydratase activities) as well as one R-domain (for feedback inhibition by phenylAlanine) that were shown to reside in discrete domains of the P- protein.
Dichapetalin-type triterpenoids and lignans from the aerial parts of Phyllanthus acutissima.
Chemical investigation of the aerial parts of Phyllanthus acutissima resulted in the isolation of five new dichapetalin-type triterpenoids, acutissimatriterpenes A-E ( 1- 5), and two new lignans,
Crystal structure of dihydrofolate reductase from Plasmodium vivax: pyrimethamine displacement linked with mutation-induced resistance.
Comparison of crystal structures of PvDHFR from wild-type and the Pyr-resistant strain as complexes with NADPH and Pyr or its analog lacking p-Cl (Pyr20) clearly shows that the steric conflict arising from the side chain of Asn-117 in the mutant enzyme is mainly responsible for the reduction in binding of Pyr.
Structures of cordypyridones A-D, antimalarial N-hydroxy- and N-methoxy-2-pyridones from the insect pathogenic fungus Cordyceps nipponica.
Bioassay-guided fractionation of the extracts from the insect pathogenic fungus Cordyceps nipponica BCC 1389 led to the isolation of N-hydroxy- and N-methoxy-2-pyridones, cordypyridone A-D, which exhibited potent in vitro antimalarial activity while their cytotoxicity was much weaker.
Aigialomycins A-E, new resorcylic macrolides from the marine mangrove fungus Aigialus parvus.
Aigialomycins A-E (2-6), new 14-membered resorcylic macrolides, were isolated together with a known hypothemycin from the mangrove fungus, Aigialus parvus BCC 5311, and exhibited in vitro antimalarial activity.
Antimalarial dihydroisocoumarins produced by Geotrichum sp., an endophytic fungus of Crassocephalum crepidioides.
Three novel dihydroisocoumarin derivatives (1-3) with antimalarial, antituberculous, and antifungal activities have been isolated by bioassay-guided fractionation from an endophytic fungus,