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A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy.
Chemotherapy and radiation therapy for cancer often have severe side effects that limit their efficacy. Because these effects are in part determined by p53-mediated apoptosis, temporary suppression… Expand
Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation
Abstractp53-dependent apoptosis contributes to the side effects of cancer treatment, and genetic or pharmacological inhibition of p53 function can increase normal tissue resistance to genotoxic… Expand
Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway
- J. E. Kravchenko, G. V. Ilyinskaya, +8 authors P. Chumakov
- Medicine, Biology
- Proceedings of the National Academy of Sciences
- 29 April 2008
Identification of unique features of cancer cells is important for defining specific and efficient therapeutic targets. Mutant p53 is present in nearly half of all cancer cases, forming a promising… Expand
p53 is a suppressor of inflammatory response in mice
- E. Komarova, Vadim I. Krivokrysenko, +11 authors A. Gudkov
- Biology, Medicine
- FASEB journal : official publication of the…
- 1 June 2005
Chronic inflammation is known to promote cancer, suggesting that negative regulation of inflammation is likely to be tumor suppressive. We found that p53 is a general inhibitor of inflammation that… Expand
p53 Involvement in the control of murine hair follicle regression.
- V. Botchkarev, E. Komarova, +6 authors B. Gilchrest
- Medicine, Biology
- The American journal of pathology
- 1 June 2001
p53 is a transcription factor mediating a variety of biological responses including apoptotic cell death. p53 was recently shown to control apoptosis in the hair follicle induced by ionizing… Expand
p53 is essential for chemotherapy-induced hair loss.
Anticancer drugs stimulate apoptosis in the hair follicles (HF) and cause hair loss, the most common side effect of chemotherapy. In a mouse model for chemotherapy-induced hair loss, we demonstrate… Expand
Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma.
The multidrug resistance-associated protein 1 (MRP1) has been closely linked to poor treatment response in several cancers, most notably neuroblastoma. Homozygous deletion of the MRP1 gene in primary… Expand
Small molecules that dramatically alter multidrug resistance phenotype by modulating the substrate specificity of P-glycoprotein
- R. Kondratov, P. Komarov, Y. Becker, A. Ewenson, A. Gudkov
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 13 November 2001
By screening a chemical library for the compounds protecting cells from adriamycin (Adr), a series of small molecules was isolated that interfered with the accumulation of Adr in mouse fibroblasts by… Expand
Reversal of multi-drug resistance in vitro by fatty acid-PEG-fatty acid diesters.
- Lela E Buckingham, M. Balasubramanian, +4 authors J. Coon
- International journal of cancer
- 3 January 1996
Fatty acid ester surfactants, e.g., Cremophor EL and Solutol HS 15, that modulate multi-drug resistance (MDR) have been described; however, the drug potential of these preparations is unclear because… Expand
p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways.
- E. Komarova, N. Neznanov, P. Komarov, M. V. Chernov, K. Wang, A. Gudkov
- The Journal of biological chemistry
Pifithrin alpha (PFTalpha) is a chemical compound isolated for its ability to suppress p53-mediated transactivation. It can protect cells from p53-mediated apoptosis induced by various stimuli and… Expand