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Structural and functional characterisation of cardiac fibroblasts.
Systems Biology: An Approach
This article illustrates that this approach is productive for the exploration of systems behavior, or “phenotypes,” at all levels of structural and functional complexity, explicitly including the supracellular domain, and suggests how this may be related conceptually to genomes and biochemical networks.
Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation.
Macrophages Facilitate Electrical Conduction in the Heart
Improved guinea-pig ventricular cell model incorporating a diadic space, IKr and IKs, and length- and tension-dependent processes.
The guinea-pig ventricular cell model, originally developed by Noble et al in 1991, has been greatly extended to include accumulation and depletion of calcium in a diadic space between the sarcolemma and the sarcoplasmic reticulum and has been found to reliably reproduce experimental observations.
Force-length relations in isolated intact cardiomyocytes subjected to dynamic changes in mechanical load.
- G. Iribe, M. Helmes, P. Kohl
- Biology, EngineeringAmerican journal of physiology. Heart and…
- 1 March 2007
The ability of the present system to independently and dynamically control preload, afterload, and transition between end-diastolic and end-systolic FL coordinates provides a valuable extension to the range of tools available for the study of single cardiomyocyte mechanics, to foster its interrelation with whole heart pathophysiology.
Effects of fibroblast-myocyte coupling on cardiac conduction and vulnerability to reentry: A computational study.
Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function
Developing a highly detailed finite-element computational model of rabbit ventricles constructed from high-resolution MR data, including the processes of segmentation, identification of relevant anatomical features, mesh generation, and myocyte orientation representation, highlights the utility of histoanatomically detailed models for investigations of cardiac function, in particular for future patient-specific modeling.
Fibroblast Network in Rabbit Sinoatrial Node: Structural and Functional Identification of Homogeneous and Heterogeneous Cell Coupling
The findings show that cardiac fibroblasts form a coupled network of cells, which may be functionally linked to myocytes in rabbit SAN, which was investigated by dye transfer in sinoatrial node tissue explants.
Mechanosensitive fibroblasts in the sino‐atrial node region of rat heart: interaction with cardiomyocytes and possible role
Results show that cardiac mechanosensitive fibroblasts could form a cellular basis for the positive chronotropic response of the heart to stretch of the right atrium.