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Multiplicity of cerebrospinal fluid functions: New challenges in health and disease
This review integrates eight aspects of cerebrospinal fluid (CSF) circulatory dynamics: formation rate, pressure, flow, volume, turnover rate, composition, recycling and reabsorption. Novel ways toExpand
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A new look at cerebrospinal fluid circulation
According to the traditional understanding of cerebrospinal fluid (CSF) physiology, the majority of CSF is produced by the choroid plexus, circulates through the ventricles, the cisterns, and theExpand
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Metabolic changes in the vicinity of brain contusions: a proton magnetic resonance spectroscopy and histology study.
Proton MR spectroscopy (1H-MRS) has been previously used to monitor metabolic changes in areas of diffuse brain injury. We studied metabolism in the close vicinity of experimental traumatic brainExpand
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The European iNPH Multicentre Study on the predictive values of resistance to CSF outflow and the CSF Tap Test in patients with idiopathic normal pressure hydrocephalus
Objective The objective was to determine the sensitivity, specificity, and positive and negative predictive values of the CSF Tap Test (CSF TT) and resistance to CSF outflow (Rout) for the outcome ofExpand
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Cerebral transplantation of encapsulated mesenchymal stem cells improves cellular pathology after experimental traumatic brain injury
PURPOSE "Naked" human mesenchymal stem cells (MSC) are neuro-protective in experimental brain injury (TBI). In a controlled cortical impact (CCI) rat model, we investigated whether encapsulated MSCExpand
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Amyloid and Tau accumulate in the brains of aged hydrocephalic rats
AD pathology is often seen in cortical biopsies of NPH patients. It remains unclear whether these findings are coincidental or causally related. In an aged animal model of NPH, we quantify Abeta andExpand
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Revisiting secondary normal pressure hydrocephalus: does it exist? A review.
OBJECTIVE There are several etiologies that can lead to the development of secondary normal pressure hydrocephalus (sNPH). The aim of this study was to evaluate the etiology, diagnosis, treatment,Expand
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One‐year outcome in the European multicentre study on iNPH
To assess the 1‐year outcome after shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH).
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Temporal profiles of cerebrospinal fluid leukotrienes, brain edema and inflammatory response following experimental brain injury
Abstract The post-traumatic changes of leukotrienes LTC4, LTD4, LTE4, and LTB4 in cerebrospinal fluid of rats from 10 min to 7 days were investigated after controlled cortical impact in relation toExpand
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Brain amyloid accumulates in aged rats with kaolin-induced hydrocephalus
Amyloid &bgr;-peptide (A&bgr;) accumulation in aged Sprague–Dawley rats (12 months) with kaolin-induced hydrocephalus was investigated by A&bgr;(1–40) and A&bgr;(1–42) immunohistochemistry at 2, 6Expand
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