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Polyamine metabolism in Acanthamoeba culbertsoni.
1,3-Diaminopropane has been identified as the major polyamine of Acanthamoeba culbertsoni and a potent polyamine oxidase was demonstrated which preferentially acted on N8-acetyl-spermidine as the substrate; free polyamines did not serve as a good substrate for this enzyme.
Polyamine metabolism as a target for growth inhibition of Acanthamoeba culbertsoni.
- S. Gupta, P. Kishore, O. Shukla
- Biology, ChemistryThe American journal of tropical medicine and…
- 1 November 1987
Methylglyoxal bis(guanyl-hydrazone) inhibited S-adenosylmethionine decarboxylase of A. culbertsoni indicating this enzyme to be the target for its antiamebic action, suggesting an alternative target for growth inhibition by this compound.
Use of 1-propylene phenoxetol and benzocaine to anaesthetise Pteria penguin (Röding, 1798) for mabe production
- P. Kishore
1-propylene phenoxetol at a concentration of 3.0 mL L-1 was the best of the anaesthetics tested and brought about anaesthesia after an average of 15 minutes with an average recovery time of 12.5 minutes, and recorded the lowest mortality of the various treatments tested.
Action of methylglyoxal bis (guanyl hydrazone) and related antiprotozoals on Acanthamoeba culbertsoni.
- P. Kishore, S. Gupta, D. K. Srivastava, O. Shukla
- Biology, ChemistryIndian journal of experimental biology
- 1 December 1990
Inhibition of S-adenosylmethionine decarboxylase and decrease in polyamine synthesis do not seem to be the primary targets for the antiamoebic action of MGBG and berenil.
Potential metabolic targets in chemotherapy for Acanthamoeba infections: polyamine metabolism.
Using high-pressure liquid chromatography, it is determined that diaminopropane (DAP) is the principal polyamine of Acanthamoeba culbertsoni, while spermidine is present in smaller quantities.
3D STRCUTURAL MODELLING FOR PROCATECHUATE 3, 4 DIOXYGENASEFROMPSEUDOMONASCEPACIABASEDONTEMPLATE OF M CHAIN FROM P. AERUGINOSA
The homology modelling is done based on the programmes to annotate protein sequence aligment with 3D structural features which helps to understand the conservation of amino acids in the specific local environment.
Action of DL-alpha-difluoromethyl ornithine on Acanthamoeba culbertsoni.
The growth and multiplication of A. culbertsoni in chemically defined medium was not affected by 1-5 mM DFMO while 10-20 mM DMFO yielded partial inhibition and a lowering of diaminopropane levels and enhancement of spermidine levels was observed in DFMO inhibited cells and level of ODC was drastically reduced in the inhibited cultures.