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Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c.
TLDR
Variation in RBC survival was large enough to cause clinically important differences in HbA1c for a given mean blood glucose. Expand
Role of the cationic residues arginine 14 and lysine 48 in the function of the cardiotonic polypeptide anthopleurin B.
TLDR
It is concluded that contrary to results from chemical modification studies, Arg-14 is not essential for the biological activity of the toxin, and Lys-48 plays a small but discernible role in the toxin-receptor interaction. Expand
Parathyroid hormone-related protein induces G1 phase growth arrest of vascular smooth muscle cells.
TLDR
It is concluded that PTHRP, by increasing intracellular cAMP, induces VSMC cycle arrest in mid-G1, secondary to a suppression in cyclin D1 and induction of p27(kip1) expression, which in turn inhibits Rb phosphorylation. Expand
Biochemical surrogate markers of hemolysis do not correlate with directly measured erythrocyte survival in sickle cell anemia
TLDR
Direct quantification of hemolysis in HbSS was directly quantified by measuring survival of an age cohort of RBCs labeled with a stable isotope, administered orally as 15N‐glycine, a metabolic precursor of heme. Expand
Evidence for Interindividual Heterogeneity in the Glucose Gradient Across the Human Red Blood Cell Membrane and Its Relationship to Hemoglobin Glycation
TLDR
The data demonstrate interindividual heterogeneity in glucose gradients across RBC membranes that may affect hemoglobin glycation and have implications for diabetes complications risk and risk assessment. Expand
Multiple cationic residues of anthopleurin B that determine high affinity and channel isoform discrimination.
TLDR
The role of cationic residues is investigated by characterizing toxin mutants in which two such residues are replaced simultaneously, which reduced affinity of the toxin for neuronal channels to a much greater extent than for cardiac channels and produced affinities only slightly lower than for ApA in each case. Expand
Importance of highly conserved anionic residues and electrostatic interactions in the activity and structure of the cardiotonic polypeptide anthopleurin B.
TLDR
It is concluded that although a negative charge per se is not essential at position 9, the presence of a hydrogen-bond forming side chain is critical both for appropriate folding and for interaction with the sodium channel. Expand
Use of an oral stable isotope label to confirm variation in red blood cell mean age that influences HbA1c interpretation
TLDR
The characteristics of the stable isotope method support its suitability for studies to directly evaluate the impact of variation in MRBC on the interpretation of HbA1c and suggests that the MRBC is stable over time but varies substantially among individuals, and supports the importance of its variation in Hb a1c interpretation. Expand
Biochemical Surrogate Markers of Hemolysis Do Not Correlate with Directly Measured Erythrocyte Survival in Sickle Cell Anemia
TLDR
RBC labeling with orally administered 15 N-glycine RBC labeling is a safe and practical method to measure RBC survival directly, and thereby quantify hemolysis. Expand
Parathyroid hormone-related protein induces G 1 phase growth arrest of vascular smooth muscle cells
Stuart, William D., Shigeto Maeda, Paramjit Khera, James A. Fagin, and Thomas L. Clemens. Parathyroid hormone-related protein induces G1 phase growth arrest of vascular smooth muscle cells. Am JExpand
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