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Topical treatment of psoriatic plaques with 1,25‐dihydroxyvitamin D3: a cell biological study
TLDR
The aim of the present study was to determine to what extent caicitriol (3 μ/g in white petrolatum) affects these parameters in vivo.
Studies on the plasma membrane of normal and psoriatic keratinocytes
TLDR
Evidence is presented to show that damage to hormone receptors is minimal and Cyclic AMP levels have been determined for the first time in isolated keratinocytes, and values were more reproducible than those reported using epidermal slices.
Methotrexate revisited: effects of long‐term treatment in psoriasis
TLDR
In 81% of the patients treated with low‐dose methotrexate (MTX), prolonged clearance or near clearance was achieved, indicating the potent and sustained potential of MTX in the treatment of both the pustular and erythematosquamous variants of psoriasis.
Elastase, a marker for neutrophils in skin infiltrates
TLDR
The enzyme elastase (EC 3.4.37) has proved to be a convenient and extremely sensitive marker for the quantification of neutrophils in cutaneous infiltrates and was linear up to about 1000 cells per sample.
Topical treatment of pityriasis rubra pilaris with calcipotriol
TLDR
Three patients with pityriasis rubra pilaris who showed a favourable response to topical therapy with calcipotriol are reported, and analysis of markers for epidermal growth, differentiation and inflammation revealed reduction of suprabasal expression of keratin 16.
Prolonged treatment with oral retinoids in adults: no influence on the frequency and severity of spinal abnormalities
TLDR
All records of patients who underwent spinal radiographs at the request of the department of dermatology between 1983 and 1993 were reviewed and a group of 135 patients comprised the total population of retinoid‐treated patients and those patients who were investigated for possible future retinoids treatment.
Methotrexate maintenance therapy and liver damage in psoriasis
TLDR
A highly significant correlation has been shown between liver damage and the age of the patients and there was no correlation between liver biopsy classification and either the cumulative dose or the duration of methotrexate therapy.
Epidermal cell DNA content and intermediate filaments keratin 10 and vimentin after treatment of psoriasis with calcipotriol cream once daily, twice daily and in combination with clobetasone
TLDR
The aim of the present study was to determine whether the cell biological response pattern of concurrent use of calcipotriol and corticosteroids is different from calcipOTriol monotherapy.
Localized unilateral hyperhidrosis
TLDR
Measurements of the rate of evaporative water loss from other areas of the body, showed a marked left‐right difference in the sweating rate on the arms and on the legs which had not been suspected clinically.
Methotrexate inhibits the leukotriene B4 induced intraepidermal accumulation of polymorphonuclear leukocytes
TLDR
Inhibition of PMN infiltration was observed in those patients treated with methotrexate while there was no significant difference between untreated psoriatic patients and normal controls.
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