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Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats
We found that development of obesity was coupled with emergence of a progressively worsening deficit in neural reward responses. Similar changes in reward homeostasis induced by cocaine or heroin areExpand
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Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of β-secretase
Recent efforts have revealed that numerous protein-coding messenger RNAs have natural antisense transcript partners, most of which seem to be noncoding RNAs. Here we identify a conserved noncodingExpand
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Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior.
Hypocretin-1 and -2 (Hcrt-1 and Hcrt-2), also referred to as orexin-A and -B, are neuropeptides synthesized by a few thousand neurons in the lateral hypothalamus. Hypocretin-containing neuronsExpand
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  • Open Access
MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212
The X-linked transcriptional repressor methyl CpG binding protein 2 (MeCP2), known for its role in the neurodevelopmental disorder Rett syndrome, is emerging as an important regulator ofExpand
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  • Open Access
Habenular a5 nicotinic receptor subunit signalling controls nicotine intake
Genetic variation in CHRNA5, the gene encoding the a5 nicotinic acetylcholine receptor subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying mechanisms areExpand
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  • Open Access
Reward Mechanisms in Obesity: New Insights and Future Directions
  • P. Kenny
  • Psychology, Medicine
  • Neuron
  • 24 February 2011
Food is consumed in order to maintain energy balance at homeostatic levels. In addition, palatable food is also consumed for its hedonic properties independent of energy status. Such reward-relatedExpand
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  • Open Access
Striatal microRNA controls cocaine intake through CREB signaling
Cocaine addiction is characterized by a gradual loss of control over drug use, but the molecular mechanisms regulating vulnerability to this process remain unclear. Here we report that microRNA-212Expand
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  • Open Access
Bimodal modulation by nicotine of anxiety in the social interaction test: role of the dorsal hippocampus.
In conditions generating moderate levels of anxiety in the social interaction test (low light, unfamiliar arena or high light, familiar arena), parenteral administration of nicotine had bimodalExpand
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Habenular α5* nicotinic receptor signaling controls nicotine intake
Genetic variation in CHRNA5, the gene encoding the α5 nicotinic acetylcholine receptor subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying mechanisms areExpand
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  • Open Access
Common cellular and molecular mechanisms in obesity and drug addiction
  • P. Kenny
  • Psychology, Medicine
  • Nature Reviews Neuroscience
  • 1 November 2011
The hedonic properties of food can stimulate feeding behaviour even when energy requirements have been met, contributing to weight gain and obesity. Similarly, the hedonic effects of drugs of abuseExpand
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  • Open Access