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Asymmetry of substantia nigra neuronal loss in Parkinson's disease and its relevance to the mechanism of levodopa related motor fluctuations.
TLDR
A pathological study of 21 patients with Parkinson's disease of asymmetrical onset revealed significant asymmetry of degeneration of the substantia nigra with greater neuronal loss contralateral to the initially affected body side, and suggested that striatal dopamine storage is not an important determinant of duration of clinical response to levodopa doses. Expand
Comparison of motor response to apomorphine and levodopa in Parkinson's disease.
TLDR
Clinical observations support the notion that integrity of striatal post-synaptic dopamine receptors is a key determinant of responsiveness to dopaminergic treatment in Parkinson's disease. Expand
Anal sphincter dysfunction in Parkinson's disease.
TLDR
Dysfunction of the striated anal sphincter musculature may be a significant cause of constipation in some parkinsonian patients, occurring as part of the generalized extrapyramidal motor disorder. Expand
Motor response to levodopa in patients with parkinsonian motor fluctuations: a follow-up study over three years.
TLDR
A short response time to the levodopa test dose was not an invariable finding in patients with severe fluctuations, whereas all had large response amplitudes and high "off" phase disability scores. Expand
Subcutaneous apomorphine in the treatment of Parkinson's disease.
TLDR
Subcutaneous apomorphine is proposed as an effective treatment for patients with incapacitating "off" period disabilities refractory to oral medication and should be considered before experimental implantation procedures. Expand
SUBCUTANEOUS APOMORPHINE IN PARKINSONIAN ON-OFF OSCILLATIONS
TLDR
Results confirm that during off periods dopamine receptors remain responsive to stimulation and provide evidence of a new, effective, and well-tolerated treatment for the most disabling complication of long-term levodopa therapy. Expand
Levodopa peripheral pharmacokinetics and duration of motor response in Parkinson's disease.
TLDR
It is proposed that the duration of response is primarily determined by levodopa peripheral pharmacokinetics rather than by central pharmacodynamic factors associated with dopamine storage capacity. Expand
Constipation and paradoxical puborectalis contraction in anismus and Parkinson's disease: a dystonic phenomenon?
TLDR
The dysfunctional pattern of muscle recruitment resembled that characteristic of dystonia elsewhere in the body and was indistinguishable in patients with idiopathic anismus and those with extrapyramidal motor disturbance due to Parkinson's disease, suggesting that anismu may be a focal dystonic phenomenon. Expand
Asymptomatic cerebral infarction in patients with chronic atrial fibrillation.
TLDR
A retrospective analysis of 54 patients with atrial fibrillation presenting with symptoms of cerebral ischemia between 1980 and 1985 was performed, finding all infarcts were peripheral and consistent with embolism, while in three of the seven patients in sinus rhythm the asymptomatic infarCTs were lacunes. Expand
ROLE OF SUBCUTANEOUS APOMORPHINE IN PARKINSONIAN VOIDING DYSFUNCTION
TLDR
Although the effect on detrusor behaviour was variable, subcutaneous apomorphine may be of use in both the assessment and treatment of voiding dysfunction in patients with Parkinson's disease. Expand
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