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Evolution of genes and genomes on the Drosophila phylogeny
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genomeExpand
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Estimating the rate of adaptive molecular evolution in the presence of slightly deleterious mutations and population size change.
The prevalence of adaptive evolution relative to genetic drift is a central problem in molecular evolution. Methods to estimate the fraction of adaptive nucleotide substitutions (alpha) have beenExpand
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Analysis of the genome sequences of three Drosophila melanogaster spontaneous mutation accumulation lines.
We inferred the rate and properties of new spontaneous mutations in Drosophila melanogaster by carrying out whole-genome shotgun sequencing-by-synthesis of three mutation accumulation (MA) lines thatExpand
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The distribution of fitness effects of new mutations
The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics that has implications ranging from the genetic basis of complex disease to the stability of theExpand
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Joint Inference of the Distribution of Fitness Effects of Deleterious Mutations and Population Demography Based on Nucleotide Polymorphism Frequencies
The distribution of fitness effects of new mutations (DFE) is important for addressing several questions in genetics, including the nature of quantitative variation and the evolutionary fate of smallExpand
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The distribution of mutation effects on viability in Drosophila melanogaster.
Parameters of continuous distributions of effects and rates of spontaneous mutation for relative viability in Drosophila are estimated by maximum likelihood from data of two published experiments onExpand
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Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila
Spontaneous mutations are the source of genetic variation required for evolutionary change, and are therefore important for many aspects of evolutionary biology. For example, the divergence betweenExpand
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Direct Estimation of the Mitochondrial DNA Mutation Rate in Drosophila melanogaster
Mitochondrial DNA (mtDNA) variants are widely used in evolutionary genetics as markers for population history and to estimate divergence times among taxa. Inferences of species history are generallyExpand
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Spontaneous Mutation Accumulation Studies in Evolutionary Genetics
Mutation accumulation (MA) experiments, in which mutations are allowed to drift to fixation in inbred lines, have been a principal way of studying the rates and properties of new spontaneousExpand
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Genomic mutation rates for lifetime reproductive output and lifespan in Caenorhabditis elegans.
Theory concerning the evolution of sex and recombination and mutation load relies on information on rates and distributions of effects of deleterious mutations. Direct information on the genomicExpand
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