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The Marine Microbial Eukaryote Transcriptome Sequencing Project (MMETSP): Illuminating the Functional Diversity of Eukaryotic Life in the Oceans through Transcriptome Sequencing
This Community Page describes a resource of 700 transcriptomes from marine microbial eukaryotes to help understand their role in the world's oceans.
Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote
The ciliate Tetrahymena thermophila is a model organism for molecular and cellular biology. Like other ciliates, this species has separate germline and soma functions that are embodied by distinct…
Horizontal gene transfer in eukaryotic evolution
The number of well-supported cases of transfer from both prokaryotes and eukaryotes, many with significant functional implications, is now expanding rapidly and major recent trends include the important role of HGT in adaptation to certain specialized niches and the highly variable impact of H GT in different lineages.
The endosymbiotic origin, diversification and fate of plastids
- P. Keeling
- BiologyPhilosophical Transactions of the Royal Society B…
- 12 March 2010
The many twists and turns of plastid evolution each represent major evolutionary transitions, and each offers a glimpse into how genomes evolve and how cells integrate through gene transfers and protein trafficking.
The tree of eukaryotes.
Diversity and evolutionary history of plastids and their hosts.
- P. Keeling
- BiologyAmerican journal of botany
- 1 October 2004
The history of the plastid and of its various hosts is reviewed with particular attention to the number and nature of the endosymbiotic events that led to the current distribution of plastids.
A common red algal origin of the apicomplexan, dinoflagellate, and heterokont plastids
- J. Janouškovec, A. Horák, M. Oborník, J. Lukeš, P. Keeling
- BiologyProceedings of the National Academy of Sciences
- 1 June 2010
These findings support a relatively simple path of linear descent for the evolution of photosynthesis in a large proportion of algae and emphasize plastid loss in several lineages (e.g., ciliates, Cryptosporidium, and Phytophthora).
Molecular data and the evolutionary history of dinoflagellates
Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum.
- R. Waller, P. Keeling, G. McFadden
- BiologyProceedings of the National Academy of Sciences…
- 13 October 1998
This work has identified nuclear genes encoding ribosomal proteins S9 and L28 and the fatty acid biosynthetic enzymes acyl carrier protein (ACP), beta-ketoacyl-ACP synthase III (FabH), and beta-hydroxyacyL-ACP dehydratase (FabZ) that are potentially an excellent target for therapeutics directed against malaria, toxoplasmosis, and other apicomplexan-mediated diseases.
Nuclear-encoded, plastid-targeted genes suggest a single common origin for apicomplexan and dinoflagellate plastids.
Results address several outstanding issues and indicate that apicomplexan and dinoflagellate plastids appear to be the result of a single endosymbiotic event which occurred relatively early in eukaryotic evolution, also giving rise to the plastid-targeted GAPDH genes of heterokonts and cryptomonads.