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Endovascular Trophoblast Invasion: Implications for the Pathogenesis of Intrauterine Growth Retardation and Preeclampsia
Abstract Maternal uteroplacental blood flow increases during pregnancy. Altered uteroplacental blood flow is a core predictor of abnormal pregnancy. Normally, the uteroplacental arteries are invadedExpand
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Development of the placental villous tree and its consequences for fetal growth.
Co-ordinated development of the fetal villous tree of the placenta is necessary for continued fetal growth and well-being. Before fetal viability, blood vessel development within the developingExpand
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Oxygen and placental villous development: origins of fetal hypoxia.
The increasing practice of preterm delivery in the fetal interest for conditions such as pre-eclampsia or intrauterine growth restriction (IUGR) has provided an opportunity to study placentalExpand
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The anatomical basis of mouse development
Introduction. The Early Stages: From Fertilization to Implantation. The Postimplantation Embryo. Postimplantation Extra-Embryonic Development. Early Organogenesis. The Transitional Tissues: TheExpand
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Aspects of human fetoplacental vasculogenesis and angiogenesis. II. Changes during normal pregnancy.
In this second review, we describe the main morphological events which accompany the development of the fetoplacental vascular system throughout normal human pregnancy and summarize findings on theExpand
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Villous cytotrophoblast regulation of the syncytial apoptotic cascade in the human placenta
Abstract Villous trophoblast in the human placenta consists of a population of proliferating stem cells which differentiate and individually fuse into the syncytiotrophoblast. We studied theExpand
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The apoptosis cascade — morphological and immunohistochemical methods for its visualization
 Apoptosis is involved in morphogenesis of embryonic tissues as well as in homeostasis of adult organs and tissues. It is the main process by which organs maintain cell mass and at the same timeExpand
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Hypoxia favours necrotic versus apoptotic shedding of placental syncytiotrophoblast into the maternal circulation.
In the third trimester of normal pregnancy, the mother tolerates daily shedding of several grams of dying placental trophoblast into the maternal circulation. The balance between apoptotic andExpand
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Aspects of human fetoplacental vasculogenesis and angiogenesis. III. Changes in complicated pregnancies.
Patterns of fetoplacental angiogenesis vary not only during the course of a normal pregnancy but also in certain pregnancy pathologies. Here, we review some of the molecular and morphological eventsExpand
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Macrophage-Induced Apoptosis Limits Endovascular Trophoblast Invasion in the Uterine Wall of Preeclamptic Women
Impaired invasion of uteroplacental arteries by extravillous trophoblast cells is a key pathogenic mechanism of preeclampsia. We previously demonstrated that reduced trophoblast invasion intoExpand
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