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Grandisines C-G, indolizidine alkaloids from the Australian rainforest tree Elaeocarpus grandis.
TLDR
Five new indolizidine alkaloids, grandisines C, D, F, and G and (-)-isoelaeocarpiline showed receptor binding affinity for the human delta-opioid receptor with IC(50) values of 14.6, 1.55, 75.4, and 9.9 microM, respectively.
Oxygenated terpenoids from the Australian sponges Coscinoderma matthewsi and Dysidea sp., and the nudibranch Chromodoris albopunctata
The isolation and structure elucidation of seven new oxygenated terpenoids and eight known terpene metabolites from marine invertebrates collected at the Inner Gneerings Reef, South East Queensland,
10-Hydroxydarlingine, a new tropane alkaloid from the Australian proteaceous plant triunia erythrocarpa.
TLDR
T. erythrocarpa is only the seventh member of the Proteaceae to have been shown to produce alkaloids and the absolute stereochemistry of 10-hydroxydarlingine was assigned using the advanced Mosher method.
Flavonoids as opioid receptor ligands: identification and preliminary structure-activity relationships.
TLDR
The investigation of the flavonoid core is reported as a potential new scaffold for the development of opioid receptor ligands and results suggest that stereochemistry of the C2 and C3 positions is important for antagonist activity and selectivity.
Recent update on anti-dengue drug discovery.
Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues.
Further modification of salvinorin A (1a), the major active component of Salvia divinorum, has resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and activity.
Indolizidine alkaloids with delta-opioid receptor binding affinity from the leaves of Elaeocarpus fuscoides.
TLDR
It is proposed that elaeocarpenine (1) is the biogenetic precursor of isoelaeocarpine (3) and elaeOCarpines (4), and demonstrated binding affinity for the human delta-opioid receptor with IC50 values of 2.7, 35.1, 13.6, and 86.4 microM.
Isolation of thuridillins D-F, diterpene metabolites from the Australian sacoglossan mollusk Thuridilla splendens; relative configuration of the epoxylactone ring.
This first chemical study of the sacoglossan mollusk Thuridilla splendens from Mooloolaba, South East Queensland, has resulted in the isolation of three new metabolites, thuridillins D-F (1-3), and
Alkaloids with human delta-opioid receptor binding affinity from the Australian rainforest tree Peripentadenia mearsii.
TLDR
Three new pyrrolidine alkaloids, peripentonine A-C,peripentadenine A/B and C, and mearsamine were isolated from the leaves of Peripentenia mearsii and their structures determined by 1D and 2D NMR spectroscopy.
New Cytotoxic Norditerpenes from the Australian Nudibranchs Goniobranchus Splendidus and Goniobranchus Daphne
TLDR
The isolation and characterisation of six new metabolites with ‘gracilin’-type carbon skeletons and of aplytandiene-3 from the Australian nudibranch Goniobranchus splendidus revealed significant cytotoxicity against a HeLa S3 cell line by five of the new terpenes.
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