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A fluorescent natural product for ultra sensitive detection of proteins in one‐dimensional and two‐dimensional gel electrophoresis
The limit of detection in one‐dimensional gels stained with Lightning Fast protein gel stain is less than 100 pg of protein, rivaling the current limits of matrix‐assisted laser desorption/ionization‐mass spectrometry (MALDI‐MS). Expand
A gloverin-like antibacterial protein is synthesized in Helicoverpa armigera following bacterial challenge.
A bacteria inducible antibacterial protein, P2, was isolated from the old world bollworm Helicoverpa armigera and was active against the Gram-negative bacteria tested and was inactive against the gram-positive bacteria, Candida albicans, a bovine turbinate cell line, and pestivirus. Expand
Antimicrobial mode of action of secretions from the metapleural gland of Myrmecia gulosa (Australian bull ant).
The data suggest that the antimicrobial agents in metapleural secretion act primarily by disrupting the structure and function of the phospholipid bilayer of the cytoplasmic membrane. Expand
Quality, not quantity: the role of natural products and chemical proteomics in modern drug discovery.
A system-wide approach to identifying new drugable targets and their small molecule ligands will help unblock the pharmaceutical product pipelines by speeding the process of target and lead identification. Expand
Rapid screening of the antimicrobial activity of extracts and natural products.
A spectrophotometric method has been developed for the rapid measurement of the antimicrobial activity of natural products, including crude extracts or pure materials. The assay depends on theExpand
Fluoroprofile, a fluorescence‐based assay for rapid and sensitive quantitation of proteins in solution
The development of a sensitive fluorescence‐based assay for the quantitative determination of protein concentration is described, which is more sensitive than standard absorption assays such as the Bradford and Lowry assays, and has a greater dynamic range and sensitivity than other fluorescent assays. Expand
Epicocconone, a novel fluorescent compound from the fungus epicoccumnigrum.
A new class of natural fluorescent probes based on a polyketide skeleton isolated from the fungus Epicoccum nigrum with a high molar absorbtivity and a long Stokes' shift that will be useful in biotechnological applications is presented. Expand
Chemical Ecology of the Nudibranchs
The activities in this field are reviewed for the first time with particular emphasis on the defense mechanisms of nudibranchs and the chemical ecology of nudIBranchs in all stages of their life cycle. Expand
Mass spectral compatibility of four proteomics stains.
SYPRO was found to inhibit identification of cysteine and tryptophan containing peptides, which reduced protein identification. Expand
132,173-cyclopheophorbide enol, the first porphyrin isolated from a sponge
Abstract 132,173-Cyclopheophorbide enol (1) a non-metalated chlorophyll A derivative has been isolated from Darwinella oxeata (Bergquist) and its structure determined by physical and X-rayExpand