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Immunosuppressant PG490 (Triptolide) Inhibits T-cell Interleukin-2 Expression at the Level of Purine-box/Nuclear Factor of Activated T-cells and NF-κB Transcriptional Activation*
PG490 (triptolide) is a diterpene triepoxide with potent immunosuppressive and antiinflammatory properties. PG490 inhibits interleukin(IL)-2 expression by normal human peripheral blood lymphocytes…
Members of the NF90/NFAR protein group are involved in the life cycle of a positive‐strand RNA virus
A group of host factors designated as ‘NFAR proteins’ that are recruited by the replication machinery of bovine viral diarrhea virus, a close relative of the human pathogen hepatitis C virus, are described.
PG490 (Triptolide) Cooperates with Tumor Necrosis Factor-α to Induce Apoptosis in Tumor Cells*
- K. Lee, W. Chang, D. Qiu, P. Kao, G. Rosen
- Biology, ChemistryThe Journal of Biological Chemistry
- 7 May 1999
The identification of a compound that blocks T NF-α-induced activation of NF-κB may enhance the cytotoxicity of TNF-α on tumors in vivo and limit its proinflammatory effects.
Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90.
Histidine-tagged NF45 and NF90 proteins, affinity-purified on nickel chelate columns, encode a NF-AT DNA-binding activity that is enhanced following T-cell stimulation, and this enhancement is blocked when T-cells are stimulated in the presence of cyclosporin A or FK506.
NF90 Regulates Cell Cycle Exit and Terminal Myogenic Differentiation by Direct Binding to the 3′-Untranslated Region of MyoD and p21WAF1/CIP1 mRNAs*
Northwestern blotting revealed that NF90 is the principal and specific p21WAF1/CIP1 and MyoD 3′-untranslated region RNA-binding protein in developing skeletal muscles and is essential for skeletal muscle differentiation and for survival.
Purification by DNA affinity chromatography of two polypeptides that contact the NF-AT DNA binding site in the interleukin 2 promoter.
The data suggest that p45 and p90 form the constitutively expressed nuclear factor(s) proposed by Yaseen et al.
Radiation pneumonitis in mice: a severe injury model for pneumocyte engraftment from bone marrow.
Immunosuppressive and Anti-Inflammatory Mechanisms of Triptolide, the Principal Active Diterpenoid from the Chinese Medicinal Herb Tripterygium wilfordii Hook. f.
Characterisation of the terpenoids present in extracts of Tripterygium identified triptolide, a diterpenoid triepoxide, as responsible for most of the immunosuppressive, anti-inflammatory and antiproliferative effects observed in vitro.
Potassium Currents in Freshly Dissociated Uterine Myocytes from Nonpregnant and Late-Pregnant Rats
- S. Wang, M. Yoshino, J. Sui, M. Wakui, P. Kao, C. Y. Kao
- BiologyThe Journal of general physiology
- 1 December 1998
In late-pregnancy, myometrial excitability is increased by changes in K+ currents that include a suppression of the ITO, a redistribution of IK expression from large-conductance Ca2+-activated channels to smaller- conductance delayed rectifier channels, a lowered Ca2+.
Protein-arginine Methyltransferase I, the Predominant Protein-arginine Methyltransferase in Cells, Interacts with and Is Regulated by Interleukin Enhancer-binding Factor 3*
Deletion studies demonstrated that the COOH-terminal region of ILF3, which is rich in arginine, glycine, and serine, is responsible for the strong interaction between PRMT1 andILF3 and is the site of ILf3 methylation byPRMT1.