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Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria
TLDR
The experiments link SR-mediated tolerance to reduced levels of oxidant stress in bacterial cells, and inactivating this protective mechanism sensitized biofilms by several orders of magnitude to four different classes of antibiotics and markedly enhanced the efficacy of antibiotic treatment in experimental infections. Expand
Production of beta-defensins by human airway epithelia.
TLDR
Human beta-defensins mRNAs are expressed in excised surface and submucosal gland epithelia from non-CF and CF patients, and data suggest that in the lung HBD-2 expression is induced by inflammation, whereas H BD-1 may serve as a defense in the absence of inflammation. Expand
Activity of abundant antimicrobials of the human airway.
TLDR
It is found that abundant airway antimicrobial factors kill common CF pathogens, although Burkholderia was relatively resistant. Expand
Synergistic and additive killing by antimicrobial factors found in human airway surface liquid.
TLDR
The data suggest that the antibacterial potency of airway surface liquid may be significantly increased by synergistic and additive interactions between antimicrobial factors, and that increased salt concentrations that may exist in cystic fibrosis could inhibit airway defenses by diminishing these synergistic interactions. Expand
Antimicrobial peptides and proteins in the innate defense of the airway surface.
TLDR
The understanding of the innate airway defense system offers the opportunity for the development of novel therapeutic approaches. Expand
Increased epithelial uptake of protein antigens in the ileum of Crohn’s disease mediated by tumour necrosis factor α
TLDR
The findings suggest increased endosomal uptake of antigens in ileal Crohn’s disease that may be mediated by TNF-α and highlight the transcellular route of antigen uptake in barrier dysfunction and implicate the interaction between epithelial cells and the innate immune system in the development of mucosal inflammation. Expand
In vivo studies of cadmium-induced apoptosis in testicular tissue of the rat and its modulation by a chelating agent.
TLDR
Characteristic DNA migration patterns (laddering) provide evidence of apoptosis (programmed cell death) in testicular tissue of rats administered CdCl2 at a level of 0.03 mmol/kg 48 h previously. Expand
In vivo spin trapping of nitric oxide in mice.
TLDR
An in vivo spin-trapping technique combined with electron paramagnetic resonance (EPR) spectroscopy to measure nitric oxide (.NO) production in the blood circulation of conscious mice represents the first spin trapping of .NO in living animals. Expand
Inhibition of multiple phases of human immunodeficiency virus type 1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins
TLDR
A nondissociable tethered dithiane compound (1,2-dithiane-4,5-diol, 1,1-dioxide, cis; NSC 624151) has been identified, which specifically attacks the retroviral zinc fingers, but not other antiviral targets. Expand
In vitro trypanocidal activity of tetraethylthiuram disulfide and sodium diethylamine-N-carbodithioate on Trypanosoma cruzi.
TLDR
Tetraethylthiuram disulfide (disulfiram) and sodium diethylamine-N-carbodithioate (DECD) and both drugs are candidates for further study to determine if they are of potential clinical interest as a prophylactic or therapeutic agent against Chagas' disease. Expand
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