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Hot flashes: a review of pathophysiology and treatment modalities.
Many therapies are being studied for the treatment of hot flashes for individuals with cancer, yet few studies have demonstrated safe and effective clinical benefit for those who suffer from thisExpand
Biosimilars 101: considerations for U.S. oncologists in clinical practice
Biosimilars of biologics used for cancer treatment and supportive care are expected to enter the U.S. market soon. Biosimilars will be highly similar to their reference products, but unlike genericExpand
Neuropathic pain in breast cancer survivors: using the ID pain as a screening tool.
Neuropathic pain (NP) is a debilitating symptom experienced by a number of patients with cancer. We evaluated the validity of ID Pain as a screening tool for NP in breast cancer survivors using theExpand
Phase 1 study evaluating the safety, tolerability, pharmacokinetics (PK), and efficacy of AMG 510, a novel small molecule KRASG12C inhibitor, in advanced solid tumors.
3003Background: The KRASG12C mutation is found in approximately 13% of lung adenocarcinomas and 1–3% of other solid tumors, but there is no approved therapy that targets this mutation. AMG 510 is a...
Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy.
PURPOSE Trastuzumab resistance has been linked to activation of the phosphoinositol 3-kinase (PI3K) pathway. Phosphatase and tensin homolog (PTEN) is a dual phosphatase that counteracts the PI3KExpand
A Randomized, Double-blind, 2-Period, Placebo-Controlled Crossover Trial of a Sustained-Release Methylphenidate in the Treatment of Fatigue in Cancer Patients
PurposeThis study assessed the efficacy of methylphenidate versus placebo for cancer-related fatigue reduction. Other objectives were to analyze cytokine levels and to determine the effects ofExpand
Depressive symptoms and health-related quality of life in breast cancer survivors.
BACKGROUND Breast cancer diagnosis and treatment can have a profound influence on a woman's physical, psychosocial, and overall well-being. We examined the prevalence of depressive symptoms and itsExpand
Age and survival estimates in patients who have node-negative T1ab breast cancer by breast cancer subtype.
AIM This article evaluates the risk of recurrence for patients who have small node-negative breast cancer by age and tumor subtype. METHODS One thousand twelve patients with a T1a,bN0 breast cancerExpand
Effect of age and race on quality of life in young breast cancer survivors.
BACKGROUND Given their early age at diagnosis, young breast cancer survivors (YBCSs) face issues that differ widely from their older counterparts. PATIENTS AND METHODS We mailed a survey to 2209Expand