• Publications
  • Influence
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
Accurate repair of DNA double-stranded breaks by homologous recombination preserves genome integrity and inhibits tumorigenesis. Cyclic GMP–AMP synthase (cGAS) is a cytosolic DNA sensor thatExpand
  • 117
  • 9
Peptide mass fingerprint sequence coverage from differently stained proteins on two‐dimensional electrophoresis patterns by matrix assisted laser desorption/ionization‐mass spectrometry (MALDI‐MS)
Identification of proteins separated by two‐dimensional electrophoresis (2‐DE) is a necessary task to overcome the purely descriptive character of 2‐DE and a prerequisite to the construction of 2‐DEExpand
  • 183
  • 5
  • PDF
Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells.
HL-60 leukemic cells were differentiated along the neutrophilic pathway with retinoic acid (RA) or along the monocytic pathway with 1,25-dihydroxyvitamin D3 (1,25(OH)2D3). Using a high-resolutionExpand
  • 131
  • 5
  • PDF
Comparison of human COP9 signalosome and 26S proteasome ‘lid’
The human core COP9 signalosome consists of eight subunits which have been identified, cloned and sequenced. The components of COP9 signalosome possess homologies with eight non-ATPase regulatoryExpand
  • 78
  • 4
Identification of proteins from Mycobacterium tuberculosis missing in attenuated Mycobacterium bovis BCG strains
A proteome approach, combining high‐resolution two‐dimensional electrophoresis (2‐DE) with mass spectrometry, was used to compare the cellular protein composition of two virulent strains ofExpand
  • 85
  • 3
A dynamic two‐dimensional polyacrylamide gel electrophoresis database: The mycobacterial proteome via Internet
Proteome analysis by two‐dimensional polyacrylamide gel electrophoresis (2‐D PAGE) and mass spectrometry, in combination with protein chemical methods, is a powerful approach for the analysis of theExpand
  • 61
  • 3
Helicobacter pylori HP0518 affects flagellin glycosylation to alter bacterial motility
Helicobacter pylori is a human gastric pathogen associated with gastric and duodenal ulcers as well as gastric cancer. Mounting evidence suggests this pathogen's motility is prerequisite forExpand
  • 45
  • 3
Murine CD146 is widely expressed on endothelial cells and is recognized by the monoclonal antibody ME-9F1
The endothelium plays an important role in the exchange of molecules, but also of immune cells between blood and the underlying tissue. The endothelial molecule S-Endo 1 antigen (CD146) isExpand
  • 57
  • 3
Characterization of myocardial protein composition in dilated cardiomyopathy by two-dimensional gel electrophoresis.
In order to identify alterations in the myocardial protein pattern that characterize dilated cardiomyopathy (DCM), we compared, by two-dimensional gel electrophoresis, right atrial protein patternsExpand
  • 72
  • 2
Molecular and physiological characterisation of a 3-phytase from soil bacterium Klebsiella sp. ASR1
Klebsiella sp. strain ASR1 isolated from an Indonesian rice field is able to hydrolyse myo-inositol hexakis phosphate (phytate). The phytase protein was purified and characterised as a 42 kDa proteinExpand
  • 92
  • 2