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A role for the thiol isomerase protein ERP5 in platelet function.
Formation and rearrangement of disulfide bonds during the correct folding of nascent proteins is modulated by a family of enzymes known as thiol isomerases, which include protein disulfide isomeraseExpand
Extracellular disulfide exchange and the regulation of cellular function.
An emerging concept is that disulfide bonds can act as a dynamic scaffold to present mature proteins in different conformational and functional states on the cell surface. Two examples are theExpand
Quercetin inhibits collagen‐stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway
Summary.  Background: The regulation of platelet function by pharmacological agents that modulate platelet signaling has proven a successful approach to the prevention of thrombosis. A variety ofExpand
A dual role for integrin-linked kinase in platelets: regulating integrin function and α-granule secretion
Integrin-linked kinase (ILK) has been implicated in the regulation of a range of fundamental biological processes such as cell survival, growth, differentiation, and adhesion. In platelets ILKExpand
Biosynthetic Pathway Connects Cryptic Ribosomally Synthesized Posttranslationally Modified Peptide Genes with Pyrroloquinoline Alkaloids.
In an era where natural product biosynthetic gene clusters can be rapidly identified from sequenced genomes, it is unusual for the biosynthesis of an entire natural product class to remain unknown.Expand
Interrelationships between Conformational Dynamics and the Redox Chemistry of S-Nitrosothiols
An increasing number of biological roles are ascribed to S-nitrosothiol compounds. Their inherent instability in multicomponent solutions is recognized as forming the basis for their physiologicalExpand
Asymmetric phosphorylation through catalytic P(III) phosphoramidite transfer: Enantioselective synthesis of d-myo-inositol-6-phosphate
Despite the ubiquitous use of phosphoramidite chemistry in the synthesis of biophosphates, catalytic asymmetric phosphoramidite transfer remains largely unexplored for phosphate ester synthesis. WeExpand
The regulation of integrin‐linked kinase in human platelets: evidence for involvement in the regulation of integrin α2β1
Summary.  Background: Activation of the platelet integrin α2β1 is closely regulated due to the high thrombogenicity of its ligand. As a β1 interacting kinase, ILK represents a candidate intracellularExpand
Determination of Noncovalent Docking by Infrared Spectroscopy of Cold Gas-Phase Complexes
Ties That Bind Almost by definition, effective catalysts bind their substrates for a very short time—releasing them quickly after helping them react and then moving on to bind new, as yet unreacted,Expand