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Epigenetics in cancer.
Epigenetic mechanisms are essential for normal development and maintenance of tissue-specific gene expression patterns in mammals. Disruption of epigenetic processes can lead to altered gene functionExpand
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Functions of DNA methylation: islands, start sites, gene bodies and beyond
  • P. Jones
  • Biology, Medicine
  • Nature Reviews Genetics
  • 29 May 2012
DNA methylation is frequently described as a 'silencing' epigenetic mark, and indeed this function of 5-methylcytosine was originally proposed in the 1970s. Now, thanks to improved genome-scaleExpand
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Comprehensive analysis of CpG islands in human chromosomes 21 and 22
  • D. Takai, P. Jones
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 12 March 2002
CpG islands are useful markers for genes in organisms containing 5-methylcytosine in their genomes. In addition, CpG islands located in the promoter regions of genes can play important roles in geneExpand
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The fundamental role of epigenetic events in cancer
Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia and include genome-wide losses of, and regional gains in, DNA methylation. The recent explosion in ourExpand
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The Epigenomics of Cancer
Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to causeExpand
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Epigenetics in human disease and prospects for epigenetic therapy
Epigenetic mechanisms, which involve DNA and histone modifications, result in the heritable silencing of genes without a change in their coding sequence. The study of human disease has focused onExpand
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A decade of exploring the cancer epigenome — biological and translational implications
The past decade has highlighted the central role of epigenetic processes in cancer causation, progression and treatment. Next-generation sequencing is providing a window for visualizing the humanExpand
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Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells.
Expression profiling of T24 cells revealed that 17 out of 313 human miRNAs were upregulated more than 3-fold by simultaneous treatment with the chromatin-modifying drugs 5-aza-2'-deoxycytidine andExpand
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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
DNA methylation, histone modifications, and nucleosomal occupancy collaborate to cause silencing of tumor-related genes in cancer. The development of drugs that target these processes is thereforeExpand
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The Role of DNA Methylation in Mammalian Epigenetics
Genes constitute only a small proportion of the total mammalian genome, and the precise control of their expression in the presence of an overwhelming background of noncoding DNA presents aExpand
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