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Interaction of stilbene disulphonates with cloned KATP channels
In this study, we tested the effects of the stilbene disulphonates DIDS and SITS on three different types of cloned KATP channel (Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2ΔC) heterologously expressed inExpand
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Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.
Optimization of lead compound 1, through extensive use of structure-based design and a focus on PI3Kδ potency, isoform selectivity, and inhaled PK properties, led to the discovery of clinicalExpand
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N,N-Diethyl-4-[(3-hydroxyphenyl)(piperidin-4-yl)amino] benzamide derivatives: the development of diaryl amino piperidines as potent delta opioid receptor agonists with in vivo anti-nociceptive
We have investigated a series of phenolic diaryl amino piperidine delta opioid receptor agonists, establishing the importance of the phenol functional group and substitution on the piperdine nitrogenExpand
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Gel Electrophoresis. Nucleic Acids
  • P. Jones
  • Biology
  • The Journal of Steroid Biochemistry and Molecular…
  • 1 March 1998
INTRODUCTORY MATERIAL: Properties of Nucleic Acids and Nucleoproteins Methods for Labelling Nucleic Acids Types of Electrophoretic Separation Types of Gels Methods of Analyzing the Interaction ofExpand
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Some effects of experimentally‐produced cigarette smoke on the growth, vitamin C metabolism and organ weights of guinea‐pigs
Guinea‐pigs receiving a controlled dietary intake of L‐xyloascorbic acid (ascorbic acid, vitamin C) inhaled experimentally produced cigarette smoke for periods of up to 20 min each day. Growth rateExpand
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The retention of ascorbic acid by guinea-pig tissues.
1. Male and female guinea-pigs with high tissue concentrations of L-xyloascorbic acid (ascorbic acid, AA) and male guinea-pigs with high tissue concentrations of D-araboascorbic acid (isoascorbicExpand
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Retention of ascorbic acid by the guinea pig eye lens.
Abstract In guinea pigs deprived of dietary sources of ascorbic acid (vitamin C) the concentration of the vitamin falls much less rapidly in the eye lens than in the aqueous and vitreous humours. TheExpand
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