Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
Experimental analysis in the hippocampus and the neocortex and computational analysis suggests that synaptic specialization turns interneuron networks into robust gamma frequency oscillators.
Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS
- J. Geiger, T. Melcher, H. Monyer
- BiologyNeuron
- 1 July 1995
Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus.
- P. Jonas, G. Major, B. Sakmann
- BiologyJournal of Physiology
- 1 December 1993
Five of nine EPSC peak amplitude distributions were judged to be quantal, suggesting that extracellular stimulation was focal, and that the stimulus‐evoked EPSCs were unitary.
Corelease of two fast neurotransmitters at a central synapse.
- P. Jonas, J. Bischofberger, J. Sandkühler
- BiologyScience
- 17 July 1998
Results indicate that spinal interneurons release both glycine and GABA to activate functionally distinct receptors in their postsynaptic target cells.
Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
- C. Schmidt-Hieber, P. Jonas, J. Bischofberger
- BiologyNature
- 13 May 2004
It is shown that young granule cells in the adult hippocampus differ substantially from mature granules cells in both active and passive membrane properties, contributing to the induction of synaptic plasticity.
Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron–principal neuron synapse
It is shown that cholecystokinin (CCK)-expressing interneurons in rat dentate gyrus release GABA in a highly asynchronous manner, in contrast to parvalbumin (PV) interneurs, thus generating long-lasting inhibition in the brain.
Dynamic Control of Presynaptic Ca2+ Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons
- Jörg R. P. Geiger, P. Jonas
- BiologyNeuron
- 1 December 2000
Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons.
- N. Spruston, P. Jonas, B. Sakmann
- BiologyJournal of Physiology
- 15 January 1995
Property of dendritic glutamate receptor (GluR) channels were investigated using fast application of glutamate to outside‐out membrane patches isolated from the apical dendrites of CA3 and CA1 pyramidal neurons in rat hippocampal slices, suggesting that the fast and slow components were mediated by the GluR channels of the L‐alpha‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionate and NMDA type, respectively.
Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses
- E. Eggermann, I. Bucurenciu, S. P. Goswami, P. Jonas
- BiologyNature Reviews Neuroscience
- 20 December 2011
Molecular analysis suggests that in some fast central synapses, transmitter release is triggered by a small number of Ca2+ channels that are coupled toCa2+ sensors at the nanometre scale.
Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks
- M. Bartos, I. Vida, P. Jonas
- BiologyProceedings of the National Academy of Sciences…
- 16 September 2002
An interneuron network model based on experimentally determined properties was able to generate oscillatory activity with higher coherence over a broad range of frequencies (20–110 Hz), and high coherence and flexibility in frequency control emerge from the combination of synaptic properties, network structure, and electrical coupling.
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