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Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression
A good correlation between NPY peptide and mRNA expression is demonstrated, and the possible involvement of NPY and Y1 receptors in depression is sustained. Expand
Neuropeptide Y levels in ethanol-naive alcohol-preferring and nonpreferring rats and in Wistar rats after ethanol exposure.
  • C. Ehlers, T. Li, +4 authors A. Mathé
  • Chemistry, Medicine
  • Alcoholism, clinical and experimental research
  • 1 November 1998
Differences in NPY-LI in limbic areas and frontal cortex between alcohol-naive P and NP rats suggest that NPY may also play a role in risk for the development of alcohol preference either by modulating the "tension-reduction" properties of alcohol or by influencing consummatory behaviors. Expand
Neuropeptide expression in rats exposed to chronic mild stresses
Findings suggest a possible involvement of neuropeptide Y, substance P and galanin in mechanisms underlying depressive disorders and show that similar peptide changes previously demonstrated in genetic rat models also occur in the present stress-induced anhedonia model. Expand
Evidence for specific involvement of dopamine D1 and D2 receptors in the regulation of body temperature in the rat.
Results suggest that both dopamine D1 and D2 receptors are specifically involved in the regulation of body temperature in the rat, and that both receptors are antagonized by pretreatment with a selective dopamine D2 receptor antagonist. Expand
Anxiolytic-like effect of the selective Neuropeptide Y Y2 receptor antagonist BIIE0246 in the elevated plus-maze
Results suggest that BIIE0246 has an anxiolytic-like profile in the elevated plus-maze, and Y2 receptors in anxiety related behaviors are investigated. Expand
Enhancement of antipsychotic-like properties of the dopamine D2 receptor antagonist, raclopride, by the additional treatment with the 5-HT2 receptor blocking agent, ritanserin, in the rat
It is concluded that 5-HT2 receptor blockade confers a limbic profile on the DA D2 receptor antagonist to produce suppression of conditioned avoidance response (CAR) and to produce catalepsy in rats. Expand
Effects of Electroconvulsive Stimuli and MK-801 on Neuropeptide Y, Neurokinin A, and Calcitonin Gene-Related Peptide in Rat Brain
There was a parallel decrease in seizures and NPY-LI and NKA-LI changes in frontal cortex and hippocampus, respectively, and investigation of neuropeptides in brain may contribute to understanding of the mechanisms of action of antide-pressive and antipsychotic treatments and of psychotomimetic drugs. Expand
Neuropeptide Y, neurokinin A and neurotensin in brain regions of Fawn Hooded “depressed”, wistar, and Sprague dawley rats. Effects of electroconvulsive stimuli
The results indicate that NPY may play a role in depression and that changes in NPY and NKA probably constitute one of the mechanisms of ECT action. Expand
Infantile stimulation and perinatal administration of Ro 15-1788: additive anxiety-reducing effects in rats.
Results obtained with a well-validated animal model of anxiety (i.e. the elevated plus-maze) show the clearest reduction of anxiety-related behavior when postnatal handling and perinatal Ro 15-1788 administration were simultaneous. Expand
Age-dependent pharmacokinetics and effect of roscovitine on Cdk5 and Erk1/2 in the rat brain.
This is the first study describing age-dependent pharmacokinetics of roscovitine and showing the high brain exposure of infant rats to the drug, which may be a promising candidate for the treatment of brain tumors in children. Expand