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Asthma. From bronchoconstriction to airways inflammation and remodeling.
Introduction Acute Inflammation and Brief Symptoms Mechanisms: Experimentally Induced Allergic Reactions Clinical Consequences and Treatment Chronic Inflammation Site of the Inflammation in AsthmaExpand
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Remodeling in asthma and chronic obstructive lung disease.
  • P. Jeffery
  • Medicine
  • American journal of respiratory and critical care…
  • 15 November 2001
Asthma and chronic obstructive lung disease (COPD) are both inflammatory conditions of the lung associated with structural "remodeling" inappropriate to the maintenance of normal lung function. TheExpand
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Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1.
In order to determine whether the airway inflammatory cells of chronic obstructive pulmonary disease (COPD) are different from those seen in asthma, we have studied a subepithelial zone, 100 micronsExpand
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Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation
Rhinoviruses cause serious morbidity and mortality as the major etiological agents of asthma exacerbations and the common cold. A major obstacle to understanding disease pathogenesis and to theExpand
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Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity.
Little is known of the structural changes in mild asthma. We have studied the light and electron microscopic structure of lobar bronchial biopsies taken at fiberoptic bronchoscopy from 11 atopicExpand
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Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease.
  • P. Jeffery
  • Medicine
  • Proceedings of the American Thoracic Society
  • 2004
Asthma and chronic obstructive pulmonary disease (COPD) are pathologically distinct in terms of their predominant inflammatory cells and structural alterations (i.e., remodeling). However, there areExpand
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Biopsy neutrophilia, neutrophil chemokine and receptor gene expression in severe exacerbations of chronic obstructive pulmonary disease.
  • Y. Qiu, J. Zhu, +4 authors P. Jeffery
  • Medicine
  • American journal of respiratory and critical care…
  • 15 October 2003
We have applied immunohistology and in situ hybridization to bronchial biopsies of patients with chronic obstructive pulmonary disease (COPD) to examine neutrophil recruitment and to determineExpand
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Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma.
We have used immunohistochemistry and monoclonal antibodies to analyze the phenotypic composition and activation status of the cellular infiltrate of bronchial biopsies obtained by fiber opticExpand
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Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production
Acute exacerbations are the major cause of asthma morbidity, mortality, and health-care costs and are difficult to treat and prevent. The majority of asthma exacerbations are associated withExpand
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